Research Categories - Disease Mechanisms
Many HMS laboratories are exploring biological mechanisms of disease processes, applying sophisticated technologies to mechanistic and therapeutic studies. These investigations focus on a wide range of disease entities, from prevalent afflictions such as cancer, to viral diseases of epidemic proportions such as AIDS, to uncommon genetic diseases.
Related Investigators
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John Blenis, PhD
Signal transduction: nutrient and energy sensing; disease; mTOR; PI3-kinase; Ras
Explore the diverse yet overlapping intracellular transmission signals propagated by cell surface receptors that respond to extracellular growth factors, environmental conditions, and other ...

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Ronald Desrosiers, PhD
HIV and AIDS: vaccine; persistent immune response
Develop new strategies for blunting viral replication and bolstering the immune system’s ability to eradicate viral-infected T-cell reservoirs.

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Daniel Finley, PhD
Ubiquitin-dependent protein degradation and the proteasome: mechanisms and coordination; architecture; role in disease
Study of proteasome activity and its relationship to diseases caused by proteinopathies.

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James Hogle, PhD
Virus structure, mechanism of entry into cells, and replication
Perform studies on poliovirus infection; investigate the proteomic composition of virus-laden membrane vesicles; study the herpes simplex virus replication complex and nuclear egress ...

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Guo-Fu Hu, PhD
Angiogenin and its role in disease: angiogenesis, cancer, neurodegenerative diseases
Investigate angiogenin’s mechanism of action and its role in cancer and neurodegenerative disease, with a focus on prostate cancer and ALS.

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Amitinder Kaur, MD
AIDS pathogenesis and CMV opportunistic infection: SIV; vaccine; AIDS resistance
AIDS modeling in non-human primates; reactivation of latent CMV in HIV-infected individuals; innate resistance to SIV-related disease progression.

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Xuebin Qin, MD, PhD
Immune modulation to treat cancer and viral infections
CD59, the complement cascade, and disease

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Arlene Sharpe, MD, PhD
T-cell regulation and disease: chronic viral infection; autoimmunity, tumor immunotherapy, peripheral tolerance
T cell co-stimulation and its immunoregulatory role in controlling the balance between T cell activation and tolerance.

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Roger Spealman, PhD
CNS disorders: addiction; Parkinson’s disease
Studies on the mechanisms and efficacy of psychoactive drugs

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Bruce Yankner, MD, PhD
Molecular mechanisms of aging and aging-related neurodegenerative diseases
Explore aging at the molecular level, employing a systems biology approach

Sub-categories
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Clinical Disorders and Disease Etiology
- Addiction»
- Age-related macular degeneration (AMD)»
- AIDS»
- Alzheimer’s disease»
- Amyloid plaque»
- Amyloid precursor protein (APP)»
- Amyotrophic Lateral Sclerosis (ALS)»
- Anxiety»
- Atherosclerosis»
- Atherosclerotic plaque»
- Autoimmune disease»
- Bacterial infection»
- Bench-to-bedside»
- Breast cancer»
- Cancer»
- Carcinoma»
- Cardiovascular disease»
- Cervical cancer»
- Chlamydia»
- Chronic viral infection»
- CMV»
- Complex disease»
- Contact hypersensitivity»
- Cystic fibrosis lung infection»
- Cytomegalovirus»
- Cytoskeletal disease»
- Dementia»
- Dengue fever»
- Dengue hemorrhagic fever»
- Dengue Virus»
- Developing country»
- Diabetes»
- Disease genes»
- Disease prognosis»
- Drug abuse»
- Ebola virus»
- Emerging infections»
- Enteropathic bacteria»
- Epilepsy»
- Epithelial tumor»
- Filovirus»
- Flu»
- Glioblastoma»
- Hepatitis»
- Hepatitis B»
- Hepatitis C»
- Hepatocellular carcinoma»
- Herpes simplex virus»
- HHV8»
- HIV»
- HPV»
- Huntington’s disease»
- Infectious disease»
- Inflammation»
- Influenza»
- Insulin resistance»
- KSHV»
- Legionella»
- Lentivirus»
- Lentivirus infection»
- Liver cancer»
- Long-term depression (LTD)»
- Malaria»
- Marburg virus»
- Membrane-enveloped viruses»
- Metabolic disease»
- Microorganism»
- Mitochondrial dysfunction»
- Mosquito-borne illness»
- Neurodegeneration»
- Neurodegenerative disease»
- Neurological disorders»
- Opportunistic infection»
- Opportunistic pathogen»
- Organ transplant rejection»
- Osteoporosis»
- Ovarian cancer»
- Parasites»
- Parkinson’s disease»
- Pathogen»
- Poliovirus»
- Presenilin»
- Prostate cancer»
- Proteinopathy»
- Retinal degeneration»
- Retinal telangiectasia»
- Retinitis Pigmentosa»
- Salmonella»
- SARS»
- Schizophrenia»
- Side effects»
- SIV»
- SIV encephalitis»
- SIV-associated myocarditis»
- Spinal Muscular Atrophy (SMA)»
- Tropical disease»
- Vascular disease»
- Viral infection»
- Virus»
- Virus entry»
- X-linked mental retardation»
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