Research Categories - Research Tools and Instrumentation

Advanced technologies are routinely used at HMS, and several faculty members are considered leading authorities on the use of these analytical technologies in biological applications. For example, Gerhard Wagner is an expert on NMR spectroscopy, and is pioneering the use of this methodology in the analysis of protein-protein and protein-ligand interactions. James Hogle is developing improvements to fluorescence microscopy and also investigating viral entry into cells by electron microscopy. Stephen Harrison is employing electron microscopy and x-ray crystallography to analyze viral particle assembly and trafficking. James Chou is exploiting NMR for analyzing the structures of membrane proteins.

Related Investigators

  1. Daniel Finley, PhD

    Ubiquitin-dependent protein degradation and the proteasome: mechanisms and coordination; architecture; role in disease

    Study of proteasome activity and its relationship to diseases caused by proteinopathies.

  2. Amin Kassis, PhD

    Radiolabeled small molecule prodrugs for non-invasive cancer imaging and therapy

    Development of Enzyme-Mediated Cancer Imaging and Therapy (EMCIT) as a new paradigm for noninvasive radioimaging and radiotherapy (ß- and alpha-particle emitting radionuclides) of solid ...

  3. Amitinder Kaur, MD

    AIDS pathogenesis and CMV opportunistic infection: SIV; vaccine; AIDS resistance

    AIDS modeling in non-human primates; reactivation of latent CMV in HIV-infected individuals; innate resistance to SIV-related disease progression.  

  4. Roberto Kolter, PhD

    Microbial physiology

    Explore gene expression, community behavior, and biochemical aspects of bacterial biofilms; investigate microbial genomics.  

  5. Galit Lahav, PhD

    The p53 tumor suppressor as a model for studying temporal dynamics of signaling networks

    Investigate protein dynamics at the single cell level; quantification of proteins in live cells using fluorescence microscopy and mathematical modeling; cellular decision-making in cancer and healthy ...

  6. Frederick Roth, PhD

    Genomic and computational analysis of genetic interactions: protein interactions; gene function; humanized yeast and drug screening; DNA sequencing

    Developing experimental and computational technologies for mapping gene and protein interactions.  

  7. James Rowlett, PhD

    Anxiety, addiction, cognition, and sleep: pharmacotherapy, GABA receptor

    Investigate the neuropharmacological basis of psychiatric disease and addiction, employing behavioral methodologies and translational approaches.  Primary areas of research include anxiety, ...

  8. Antoine Van Oijen, PhD

    Single molecule imaging for uncovering molecular mechanisms of action: biologic and therapeutic analysis

    Dr. van Oijen’s research utilizes single molecule imaging for uncovering molecular mechanisms of action pertaining to cell fusion of enveloped viruses, DNA replication fork dynamics, and ...

  9. David Van Vactor, Jr, PhD

    Cell biology of neuronal connectivity: axon guidance; synapse; signaling mechanisms

    Studies on axon guidance and synapse formation in metazoans such as Drosophila that are in many cases directly relevant to mammalian cells.  

  10. Wei-Dong Yao, PhD

    Dopamine signaling; synaptic plasticity; neurobiology of neuropsychiatric and neurodegenerative disorders