Research Categories - Therapeutics

The range of studies that address therapeutics is expansive, encompassing biologic and cell-based therapies, small molecules, and diagnostics. Some examples include chimeric proteins for improving targeted therapy, stem cells for treating neurodegenerative diseases, radiolabeled prodrugs designed to offload cytotoxic activity only at the sites of tumors, and novel natural products having antibiotic properties.

Related Investigators

  1. John Blenis, PhD

    Signal transduction: nutrient and energy sensing; disease; mTOR; PI3-kinase; Ras

    Explore the diverse yet overlapping intracellular transmission signals propagated by cell surface receptors that respond to extracellular growth factors, environmental conditions, and other ...

  2. Martin Dorf, PhD

    Molecular signaling in inflammation: TNF; cytokine; autoimmune disease; T-cell

    Investigate the biochemical signaling perturbations elicited by the pro-inflammatory cytokine TNF that serve to modulate the activation of NF-кB, with a focus on TNF receptor-associated factor ...

  3. Michael Farzan, PhD

    VIRAL ENTRY AND ANTI-VIRAL STRATEGIES Viral Receptors; HIV Therapy; Dengue Virus; SARS; Ebola Virus

    Undertake translational studies geared toward the development of novel peptide mimetic inhibitors of HlV binding to its cell surface receptor, modeled after the CD4 and CCR5 HIV receptor/co-receptor; ...

  4. Guo-Fu Hu, PhD

    Angiogenin and its role in disease: angiogenesis, cancer, neurodegenerative diseases

    Investigate angiogenin’s mechanism of action and its role in cancer and neurodegenerative disease, with a focus on prostate cancer and ALS.  

  5. Amitinder Kaur, MD

    AIDS pathogenesis and CMV opportunistic infection: SIV; vaccine; AIDS resistance

    AIDS modeling in non-human primates; reactivation of latent CMV in HIV-infected individuals; innate resistance to SIV-related disease progression.  

  6. Roberto Kolter, PhD

    Microbial physiology

    Explore gene expression, community behavior, and biochemical aspects of bacterial biofilms; investigate microbial genomics.  

  7. Keith Mansfield, DVM

    Infectious diseases and aging: simian AIDS; opportunistic infection; diet

    Infectious diseases, aging, and dietary intervention.

  8. Samara Reck-Peterson, PhD

    Intracellular cargo movement: the role of molecular motors

    Explore the role of dynein in molecular cargo transport

  9. Pamela Silver, PhD

    Systems and synthetic biology: gene expression; synthetic proteins; biofuel

    Investigate a wide spectrum of biological phenomena. Starting with gene regulation as a core theme, investigate nuclear spatial architecture, synthetic biology, epigenetics, systems biology, ...

  10. Roger Spealman, PhD

    CNS disorders: addiction; Parkinson’s disease

    Studies on the mechanisms and efficacy of psychoactive drugs