Research Categories - Therapeutic Discovery Tools and Assays
Innovative DNA sequencing procedures, high throughput screening assays for genetic studies and small molecule inhibitors, and computational analysis of signaling pathways are just some of the methodologies that are being employed for diagnostic and therapeutic discovery purposes.
Related Investigators
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Constance Cepko, PhD
Retina development and pathophysiology
Investigate the mechanisms of the development of different retinal cell types derived from multipotent retinal progenitor cells with a focus on photoreceptor cells; study the pathological loss of ...
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Jeremy Gunawardena, PhD
Experimental and theoretical analysis of signal transduction: EGF signaling, drug efficacy, phosphorylation states, microfluidics, formalized biology language
Investigate the dynamics of signal transduction, from a mechanistic and practical perspective. Describe at a fundamental level the input/output transformation that connects external signals to ...
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James Hogle, PhD
Virus structure, mechanism of entry into cells, and replication
Perform studies on poliovirus infection; investigate the proteomic composition of virus-laden membrane vesicles; study the herpes simplex virus replication complex and nuclear egress ...
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Amin Kassis, PhD
Radiolabeled small molecule prodrugs for non-invasive cancer imaging and therapy
Development of Enzyme-Mediated Cancer Imaging and Therapy (EMCIT) as a new paradigm for noninvasive radioimaging and radiotherapy (ß- and alpha-particle emitting radionuclides) of solid ...
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Galit Lahav, PhD
The p53 tumor suppressor as a model for studying temporal dynamics of signaling networks
Investigate protein dynamics at the single cell level; quantification of proteins in live cells using fluorescence microscopy and mathematical modeling; cellular decision-making in cancer and healthy ...
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Xuebin Qin, MD, PhD
Immune modulation to treat cancer and viral infections
CD59, the complement cascade, and disease
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Yang Shi, PhD
Histone demethylation and gene regulation: gene expression; epigenetics; disease
Studies on lysine-specific demethylases and biochemical and functional aspects of histone demethylation.
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David Sinclair, PhD
Sirtuins in aging and disease: calorie restriction; mitochondria; cancer; diabetes
Study sirtuin pathways, their role in multiple diseases and their lifespan extension capabilities.
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Roger Spealman, PhD
CNS disorders: addiction; Parkinson’s disease
Studies on the mechanisms and efficacy of psychoactive drugs
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David Van Vactor, Jr, PhD
Cell biology of neuronal connectivity: axon guidance; synapse; signaling mechanisms
Studies on axon guidance and synapse formation in metazoans such as Drosophila that are in many cases directly relevant to mammalian cells.
