Research Categories - Diagnostics
Signal transduction: nutrient and energy sensing; disease; mTOR; PI3-kinase; Ras
Explore the diverse yet overlapping intracellular transmission signals propagated by cell surface receptors that respond to extracellular growth factors, environmental conditions, and other ...
Personal Genome Project
Genomic DNA Sequencing Technologies; Gene Synthesis; Biofuel
Molecular signaling in inflammation: TNF; cytokine; autoimmune disease; T-cell
Investigate the biochemical signaling perturbations elicited by the pro-inflammatory cytokine TNF that serve to modulate the activation of NF-кB, with a focus on TNF receptor-associated factor ...
Targeting protein translation for anticancer therapies; CD59 and diabetes
Employ the preclinical resources of the Laboratory for Translational Research to develop new therapies and diagnostics in oncology and diabetes
Radiolabeled small molecule prodrugs for non-invasive cancer imaging and therapy
Development of Enzyme-Mediated Cancer Imaging and Therapy (EMCIT) as a new paradigm for noninvasive radioimaging and radiotherapy (ß- and alpha-particle emitting radionuclides) of solid ...
T-cell regulation and disease: chronic viral infection; autoimmunity, tumor immunotherapy, peripheral tolerance
T cell co-stimulation and its immunoregulatory role in controlling the balance between T cell activation and tolerance.
Molecular mechanisms of aging and aging-related neurodegenerative diseases
Explore aging at the molecular level, employing a systems biology approach