Research Categories - Diagnostics

The ability to diagnose disease at its earliest conception, offer prognostic ability, and assess the efficacy of therapeutic intervention by minimally invasive procedures will be a critical component of effective health care in the future. HMS has several exciting initiatives in the diagnostic arena, including detection of circulating tumor cells, a biomarker for diabetes, an imaging agent for melanoma, and a visionary approach to achieving an affordable personal genome.

Related Investigators

  1. John Blenis, PhD

    Signal transduction: nutrient and energy sensing; disease; mTOR; PI3-kinase; Ras

    Explore the diverse yet overlapping intracellular transmission signals propagated by cell surface receptors that respond to extracellular growth factors, environmental conditions, and other ...

  2. George Church, PhD

    Personal Genome Project

    Genomic DNA Sequencing Technologies; Gene Synthesis; Biofuel

  3. Martin Dorf, PhD

    Molecular signaling in inflammation: TNF; cytokine; autoimmune disease; T-cell

    Investigate the biochemical signaling perturbations elicited by the pro-inflammatory cytokine TNF that serve to modulate the activation of NF-кB, with a focus on TNF receptor-associated factor ...

  4. Jose Halperin, MD

    Targeting protein translation for anticancer therapies; CD59 and diabetes

    Employ the preclinical resources of the Laboratory for Translational Research to develop new therapies and diagnostics in oncology and diabetes

  5. Amin Kassis, PhD

    Radiolabeled small molecule prodrugs for non-invasive cancer imaging and therapy

    Development of Enzyme-Mediated Cancer Imaging and Therapy (EMCIT) as a new paradigm for noninvasive radioimaging and radiotherapy (ß- and alpha-particle emitting radionuclides) of solid ...

  6. Arlene Sharpe, MD, PhD

    T-cell regulation and disease: chronic viral infection; autoimmunity, tumor immunotherapy, peripheral tolerance

    T cell co-stimulation and its immunoregulatory role in controlling the balance between T cell activation and tolerance.  

  7. Bruce Yankner, MD, PhD

    Molecular mechanisms of aging and aging-related neurodegenerative diseases

    Explore aging at the molecular level, employing a systems biology approach