Enhancers of synaptic connectivity for treatment of neurological disorders

Summary

Synaptic deficiency is a hallmark of many neurological disorders.  Defective synapse development — leading to suboptimal numbers of functional excitatory synapses in the brain — is a common causative feature seen in early developmental disorders, as well as in aging and neurodegeneration.

By deploying a high-content screen on primary neurons using bio-imaging of synaptic markers, researchers in the Greenberg lab at Harvard Medical School have identified a series of chemical and natural compounds that promote synapse development and enhance synapse density. These compounds could be developed as a possible treatment for synaptic deficiency.

We are seeking a partner to support further validation and development of the compounds.

Intellectual Property Status: Patent(s) Pending

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