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Biomedical Research Tools

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Results: 174
Case # Lead Inventor Title
3527Fontana, WalterLifespan Machine
3511Sinclair, David A.Non-fluorometric assay for the activity of sirtuins (Class III HDACs) and other NAD-cleaving enzymes
3495Wu, Chao-TingOligopainting
3494Parker, Kevin KitEngineered cardiac muscle with embedded neural networks as a tool to accelerate cardiac maturation in vitro; Co-culture method for maturing cardiomyocytes
3473Nagai, ShigemiNovel osteoinductive peptides to enhance bone regeneration
3469Sorger, Peter K.Knockout mouse model for human liver cancer
3468Crozier, Kenneth B.Fresnel zone plate scanning devices could replace conventional microscopes
3437Salic, AdrianMetabolic labeling and direct imaging of choline-containing; phospholipids in vivo
3350Grusby, Michael J.CD1-deficient mice
3295Kirschner, Marc W.Diagnostics/biomarker identification based on large scale post translational modifications in cellular extracts/serum/CSF
3263Sanes, Joshua R.Anti-Dscam monoclonal antibodies for studying the establishment of neural circuits.
3211Park, HongkunVertical Silicon Nanowires as a Universal Platform for Highly Efficient Delivery of Bioactive Molecules into Living Cells
3197Melton, DouglasUsing (-)-indolactam V to induce differentiation of human and mouse embryonic stem cells into pancreatic lineage
3196Whitesides, George M.Fabrication of ultra-thin films of ionotropic hydrogels
3189Wong, Wesley PhilipNew Instrument for Massively Parallel Single Molecule Binding Measurements
3175Tschumperlin, Daniel J.High-throughput hydrogels for cell culture in realistic tissue stiffness environments
3157Nagai, ShigemiNovel high throughput biopanning assay to screen bioactive peptides that mimic functions of extracellular matrix for effective scaffold
3151Walz, ThomasAffinity grids in preparing single particle specimens for Electron Microscopy
3116Kassis, Amin I.Detection of Solid Tumor Signatures in Blood of Cancer Patients
3045Crozier, Kenneth B.Microfabricated, Chip-Based, Low-Power Optical Tweezers
3041Whitesides, George M.Microfluidic platform for constructing tunable 3D cellular microenvironments for performing biologically relevant cell-based assays
3017Yellen, GaryA Real Time Sensor of ATP/ADP Ratio for Analytical Assays
2996LaBaer, JoshuaKinome Survey of Molecular Pathways Lead to Tamoxifen-Resistant Breast Cancer Growth
2983Fredberg, JeffreyRealistic reproduction of a cell's dynamic physical environment
2965Van Oijen, Antoine M.A Method to Visualize and Characterize Fusion of Single Membrane-Enveloped Viruses with Target Membranes
2963Gygi, Steven P.A technology for a mass spectrometry-based in vitro kinome activity assay
2956Roth, Frederick P.Methods and Applications for Stitched DNA Barcodes
2945Turney, Stephen GarnetMethod of Thick Specimen Imaging
2929Crozier, Kenneth B.Optical tweezers get smaller, sharper, and less expensive
2905Chou, James J.DNA Nanotube Liquid Crystals for NMR Structure Determination
2889Sanes, Joshua R.Corticospinal tract (CST)-YFP transgenic mice for monitoring axonal responses to spinal cord injury
2886DiRienzo, Albert G.Novel and Efficient Algorithm for Analyzing Large Genotypic and Phenotypic Data Sets in Clinical Trials
2882Benenson, YaakovBiological Computers: In Vivo Autonomous Doctors that Diagnose and Treat Disease
2868Schreiber, Stuart L.Novel Urazole Epoxyquinol Inhibitors of Hepatitis C Virus Replication
2830Gygi, Steven P.Decipheration of Phosphorylation Patterns
2768Weitz, David A.Novel surfactants for stabilizing emulsions of water or hydrocarbon oil-based droplets in a fluorocarbon oil continuous phase
2756Sanes, Joshua R.Anti-SAD-A monoclonal antibody for studying pre-synaptic differentiation and neuronal polarization
2715Whitesides, George M.Antibody purification
2681Wessling-Resnick, MarianneHEK293T cells stably expressing Divalent Metal Transporter-1 (DMT1-1): Model System to Screen for Inhibitors of Iron Uptake
2669Vallee, Bert L.Treating Diseases Associated with Oxidative Stress through the Metalothioneine System
2662Church, George M.Multiplex Circle Sequencing: An Improved Method for Haplotyping
2639Larson, Dale N.Smaller and faster biocalorimeter for ultra-sensitive temperature sensing that helps reduce drug-development cost and risk
2633Pizzagalli, Diego A.A Novel Screening Method for Assessment of Psychopathologic Disorders
2627Bonni, AzadTargeting MEF-2 for the Treatment of Neurodegenerative Disease
2612Lichtman, J. W.Transgenic Mice with Fluorescently Tagged Neuronal Mitochondria as a New Tool to Study Axonal Transport
2611Lichtman, J. W.Brainbow Mice: A Technicolor Approach to map the Neuronal Circuits
2572Marcus, Charles M.Enhanced high resolution nanoparticle-based molecular imaging via MRI
2568Whelan, Sean P.J.Attenuated RNA Viruses for Vacine and Drug Delivery
2560Shaw, Jared T.Targeting FtsZ Activity Using Novel Antibacterials: Screening Assays, Small Molecule Hits, and Synthetic Pathways to Potent Natural Products
2559McMahon, Andrew P.Wnt1-Cre transgenic mouse model
2514Ploegh, Hidde L.Single Cell mAB Discovery: ; Discovering Therapeutic Antibodies Invisible to Current Screening Platforms
2505Kunes, SamProteasome-Mediated Degradation of RISC: Lead Target for Treatment of Long-Term Memory Disorders
2493Tsai, Li-HueiTargeting the Par-4 Protein as a Novel Approach in Depression Treatment
2438Myers, Andrew G.Natural Product Avrainvillamide and its Analogs as Targeted Anticancer Agents
2424Walsh, Christopher T.Correlated Mutation Analysis-assisted Chimeric-Engineering/Directed-Evolution of Novel Portein/Enzyme Function
2419Harn, Donald AlfredA Novel Class of HIV Therapeutics: Monoclonal Antibodies that Neutralize Previously Resistant HIV Primary Isolates
2406Roth, Frederick P.Simultaneous Study of Multiple Genetic Interactions Using Multi-mutant Yeast
2384Nibert, Max L.Determination of Intracellular Protein-Protein Interactions
2332Westervelt, Robert M.Fully-integrated 2D microelectromagnet coil arrays in silicon for magnetic manipulation and RF imaging of cells and magnetic particles
2307Church, George M.Amplification of trace amounts of nucleic acids
2301Goldberg, Alfred L.Novel Candidates for Tuberculosis Therapy
2276Lieber, Charles M.Transformation of a semiconducting nanowire into a conducting nanowire in a controllable way
2261Church, George M.Modular Conditional Knockout: Precise Temporal Control of Protein Degradation in Living Cells
2258Church, George M.Bead-based polymerase colony microarrays and nucleic acid sequencing ("Polony-FISSEQ Beads")
2230King, Randall W.A Novel Class of Proteosome Inhibitors
2227Church, George M.Multiplexing long DNA syntheses
2215Stone, Howard A.Method and Apparatus for Fluid Dispersion
2212Dowling, John E.Using Zebrafish for clues about human vision loss
2203Kobzik, LesterMonoclonal IgE anti-ovalbumin antibody
2196Kramnik, IgorSusceptibility to Tuberculosis 1 (sst1): Novel Target for Diagnosis and Treatment of Mycobacterium tuberculosis
2193Myers, Andrew G.Saframycin Assay
2172Kirschner, Marc W.Elucidating Novel Protein Interactions Using MALDI-MS and a Self-Assembled Monolayer Chip
2170Hotamisligil, Gokhan S.Animal Model of Diabetes and Obesity: Cross-bred JNK1 KO/JNK 2 KO Mice
2163Liu, David R.In Vivo Evolution of an RNA-Based Transcriptional Activator
2161Tsai, Li-HueiTransgenic mouse model for neurodegenerative disease
2144McMahon, Andrew P.Col 2A promoter Cre transgenic mice
2129Verdine, Gregory L.Mu Opioid Peptidomimetics: Lead Compounds for the Treatment of Pain
2070Schaak, DianeToxin-Phage Bacteriocide Antibiotic and Uses Thereof
2060Schreiber, Stuart L.Anti-Mitotic Eg5 Inhibitors for Treatment of Cancer and Inflammatory Disease
2052Mitchison, Timothy J.Phenotype Drug Screening Platform ; Based on Quantitative Morphometric Analysis of Cells
2046Church, George M.DNA Memory
2032Shi, YangA DNA vector-based RNAi technology to suppress gene expression in mammalian cells
2024Church, George M.MicroArray Spot LINEar Regression (MASLINER) software
1992Banaji, Mahzarin R.Interactive Program for Determining Implicit Attitudes
1974Hunter, CraigSID Proteins Enable Gene Silencing by Systemic RNAi
1955Howley, Peter M.Human herpesvirus-7 glycoprotein U21
1947Roth, Frederick P.GoFish gene annotation and database query software
1934Liu, Jun S.Algorithm for Haplotype Construction of Single Nucleotide Polymorphism
1918Gygi, Steven P.Absolute Quantification of Proteins (AQUA)
1917Schreiber, Stuart L.HDAC Inhibitors
1911Wagner, GerhardTreeDock protein docking software
1903Coen, Donald M.A Sensitive Assay to Identify Inhibitors of HSV DNA Polymerase
1885Liu, David R.Nonhomologous Random Recombination of Nucleic Acids (Nucleic Acid Shuffling)
1884Gygi, Steven P.Microcapillary Column Peptide Trap
1882Myrick, Kyl V.A Versatile Method for Accelerated Chromosome Walking and DNA Fingerprinting
1872Kirschner, Marc W.Targeting FtsZ Activity Using Novel Antibacterials: Screening Assays, Small Molecule Hits, and Synthetic Pathways to Potent Natural Products
1836Rando, Robert R.Aminoglycosides Scaffolding Targeting Antibiotic-Resistant Bacteria
1823Verdine, Gregory L.A Drug Discovery Platform Using Novel Labeled Uridine Analogs: Unique moieties contribute to molecular biology research
1821Church, George M.Time and concentration warping software for RNA and protein expression data
1816Lieber, Charles M.High-yield fabrication of single-walled carbon nanotube probe tips for atomic force microscopy
1793Ho, I ChengA Novel Class of Phospholipase A2 Preferentially Expressed in Th2 Cells
1781Walsh, Christopher T.Techniques for high yield synthesis of macrocyclic compounds
1776Munger, KarlMethods to Regulate the Duration of Th2 Activation
1740Rubin, Eric JosephHyperactive mutant of the Himar1 mariner transposase
1699Kim, Tae Kookp53 cell-Based assay
1690Shair, Matthew D.Reaction Microarrays: Ultra Fast Method for Chiral Catalyst Discovery
1675Schreiber, Stuart L.Identification and Characterization of Class II HDACs: Lead Targets for Treatment of Cancer and Neurodegenerative Diseases
1659Yuan, Zhi-MinIdentification of a Sequence Element from p53 that Signals for Mdm2-targeted Deg
1657Yuan, JunyingDrug candidate for neurological stroke and septic shock
1633Schreiber, Stuart L.Small Molecule Arrays: A New Forefront in Drug Discovery
1625McKeon, Frank D.Calcipressins: Lead Targets for Autoimmune, Inflammatory, and Cardiovascular Disease
1613Coen, Donald M.Inhibitors of Protein-Processivity Factor
1603Falchuk, Kenneth H.Bilins as anticancer agents
1591Corey, Elias J.Direct and Practical Synthetic Route to Pseudopterosins: Important Anti-Inflammatory, Anti-Pain, and Anti-Irritant Compounds
1587David, John R.Migration Inhibitory Factor (MIF) Knockout Mouse
1554Yuan, JunyingSmall Molecule Therapeutic and Screening Assays for Drugs Active Against Chronic Neural Degenerative Diseases.
1546Knipe, David M.Drug screening tool for herpes antivirals
1539Mitchison, Timothy J.On Bead Tagging and Decoding for Combinatorial Synthesis
1534Howley, Peter M.A Method to Target the Degradation of Specific Cellular Proteins
1528Hogle, James M.A Tool for the Linkage and Presentation of Multiple Protein Functional Domains
1513Schreiber, Stuart L.The Cytoblot: A Miniaturized High-Throughput Immunodetection Screening Assay Kit
1502Erikson, Raymond LeoPolo-Like Kinase Polo Box: Lead Target for Cancer Therapeutics
1492Kirschner, Marc W.Geminin: A Biomarker with Significant Prognostic Potential in Cancer and Neuronal Differentiation
1490Wilcox, Heather M.Monoclonal Antibody 2F12, Anti-ITK
1487Schreiber, Stuart L.High-Throughput Synthetic Platform for Natural Product Analog Libraries
1486Howley, Peter M.Compositions and Methods for Treating Papillomavirus-Infected Cells
1475Mekalanos, John J.Systematic, condition-independent identification of essential genes of microorganisms
1472Verdine, Gregory L.Synthesis of Compounds with Peptide Characteristics
1452Shi, ChengweiCellular Basis of Vascular-Graft Stenosis
1451Church, George M.AlignAce motif searching software
1441Glimcher, LaurieTranscription HXBP-1 Factor Fragment
1439Church, George M.Surface-Bound Double-Stranded DNA Protein Arrays
1438Church, George M.Production and uses of polymerase colony ("polony") arrays
1434Wang, James C.Plasmids Overexpressing E.coli DNA Gyrase Subunits A and B
1426Struhl, KevinA Rapid and Inducible Method for Repressing Gene Function
1416Hogle, James M.Novel Chemistry and Method to make Compounds Active Against Picornaviruses
1407Kirschner, Marc W.Method for Cloning Secreted Proteins
1391Melton, DouglasCell Based Assay for Discovery of Glycogen Synthase Kinase Inhibitors
1373Maggio, JohnHBPA Photoaffinity Probe
1372Whitman, Malcolm R.Methods and Reagents for Modulating TGF-beta Superfamily Signalling
1365Fett, James W.Antisense Inhibition of Angiogenin Expression in Cancer
1329Beverley, Stephen M.New Delivery Device for Protein Therapeutics and Vaccines
1276Samson, Leona D.3-methyladenine Glycosylase
1275Ptashne, MarkSmall Molecule Transcriptional Activators: Lead Agents for Gene Therapy
1261Glimcher, LaurieMonoclonal Antibodies to CIITA (Class II Transactivator) Protein
1250Schreiber, Stuart L.Identification and Characterization of Class II HDACs: Lead Targets for Treatment of Cancer and Neurodegenerative Diseases
1248Wessling-Resnick, MarianneSFT: An Iron Transport Protein
1246Lee, Arthur Mu-EnSmooth Muscle Cell Lim Protein
1216Knipe, David M.Herpesvirus Antiviral Drug Screen
1188Wong, David T. W.A Novel Tumor Suppressor Protein and Gene
1173Coen, Donald M.High Lead Expression of Soluble CMV UL97 and Development of an Assay to Screen Inhibitors
1139Shi, Michael MingRat Macrophage Inflammatory Protein (MIP-1 alpha) cDNA Clone
1130Telford, Sam R.A Strain of the Ehrlichial Agent
1127Swanson, JoelLiposome- Based, Intracellular Delivery of Drugs into Phagocytes, B- and T- cells and their tumor cells.
1119Leder, PhilipEotaxin: an Eosinophil Chemoattractant
1055Lee, Arthur Mu-EnIsolation and Characterization of Genes Preferentially Expressed in the Aorta
1049Strominger, Jack L.NF-X1: Novel Target for Inhibition of MHC Class II Transcription and Autoimmune Disease
1014Kirschner, Marc W.Receptor-Ligand Assay for orphan tyrosine kinase receptors
0962Strominger, Jack L.LB3.1 Monoclonal Antibody
0951Russell, MaryMediators of Chronic Allograft Rejection and DNA Molecules Encoding Them
0924Maniatis, ThomasSC-35 Specific Monoclonal Antibody
0898Halperin, Jose A.Methods for Treating Arteriosclerosis
0878Wang, NingDevice and System for Measurement of Mechanical Properties of Molecules and Cell
0806Essex, Myron EDeglycosylating gp120
0804Rando, Robert R.ras Oncogene Inhibitors
0794Wiley, Don C.Production of Class I Major Histocompatibility Molecules Complexed with Single A
0730Benjamin, Mark B.Cell Lines and Methods for Assaying Human Interchromosomal Recombination
0713Wang, James C.Topoisomerase clone, pJW 312Sal
0699Goldberg, Alfred L.Inhibition of ubiquitination or proteasome activity to treat muscle wasting.
0692Folkman, M. JudahPurification of a Smooth Muscle Cell Mitogen from Beta Tumor Cell Conditioned Me
0627Berson, EliotSeries of Genetic Mutations Characterizing Retinitis Pigmentosa: Probe Compositions and Relevant Animal Models
0593Strominger, Jack L.DNA Probe HLA-DQ alpha
0551Leder, PhilipAnimal Model for Benign Prostate Hyperplasia
0510Ribeiro, JoseVasodilatory and Immune Suppressant Peptides (formerly Salivary Gland of Flies)