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Results: 107
Case # Lead Inventor Title
3622von Andrian, Ulrich H.Novel target in NK cell mediated antigen specific memory responses
3576Haigis, Marcia C.The role of SIRT5 in lipid and cholesterol homeostasis (SIRT5 biologies)
3494Parker, Kevin KitEngineered cardiac muscle with embedded neural networks as a tool to accelerate cardiac maturation in vitro; Co-culture method for maturing cardiomyocytes
3473Nagai, ShigemiNovel osteoinductive peptides to enhance bone regeneration
3469Sorger, Peter K.Knockout mouse model for human liver cancer
3461Cepko, Constance L.Gluconeogenesis as a pro-survival treatment for neurons under stress
3430Ritter, TobiasNovel pain therapeutics to improve tolerance and activity
3358Corey, Elias J.Novel Antiangiogenic Agents Inspired by Cortistatin A: Next generation therapeutics for macular degeneration and cancer
3350Grusby, Michael J.CD1-deficient mice
3289Hu, GuofuUse of neamine for treating prostate cancer
3279Sharpe, Arlene H.Method for generating regulatory T cells and mainataining them
3277Haigis, Marcia C.Inhibition of Sirt4 for treatment of obesity and enhancing fat metabolism
3157Nagai, ShigemiNovel high throughput biopanning assay to screen bioactive peptides that mimic functions of extracellular matrix for effective scaffold
3133Harrison, Stephen C.A fusion intermediate state of HIV-1 gp41, targeted by broadly neutralizing antibodies, for purposes of vaccination
3116Kassis, Amin I.Detection of Solid Tumor Signatures in Blood of Cancer Patients
3094Cepko, Constance L.Protection of cone cells by HDAC4 mediated Hif1alpha activation in normal and diseased retinas
3076Yuan, JunyingSmall molecule regulators of autophagy identified by an image-based high throughput screen
2997Lory, StephenSmall-molecule inhibitors of Chlamydia cell growth
2965Van Oijen, Antoine M.A Method to Visualize and Characterize Fusion of Single Membrane-Enveloped Viruses with Target Membranes
2963Gygi, Steven P.A technology for a mass spectrometry-based in vitro kinome activity assay
2954Schreiber, Stuart L.Non-ATP competitive Inhibitors of Aurora Kinases: Selective and Potent Cancer Treatment
2937Qin, XuebinApplication of Domain 4 of ILY for treatment and prevention of foreign ; pathogen infection
2911Silver, PamelaProtein Based Therapies using Quantitatively Designed Proteins
2904Hu, GuofuAngiogenin loss-of-function mutations in amyotrophic lateral sclerosis
2889Sanes, Joshua R.Corticospinal tract (CST)-YFP transgenic mice for monitoring axonal responses to spinal cord injury
2887Qin, XuebinInhibitor of CD59 Activity as an Adjunct to Antibody-Based Cancer Therapy
2868Schreiber, Stuart L.Novel Urazole Epoxyquinol Inhibitors of Hepatitis C Virus Replication
2858Desrosiers, Ronald C.AIDS vaccine using gamma-2 herpesvirus as a vector to express lentiviral (AIDS virus) genes
2816Thatte, Hemant S.The Somah Solution - Enabling a Revolution in Transplantation:; Dramatic Enhancement of transplant organ viability and storage time, Improved donor-recipient matching; Harvesting of organs from non-beating heart donors; And – the ideal cardioplegia and other organ perfusion solution
2785Schreiber, Stuart L.SMERs: Small Molecule Enhancers for Treatment of Cancer and Neurodegenerative Diseases
2681Wessling-Resnick, MarianneHEK293T cells stably expressing Divalent Metal Transporter-1 (DMT1-1): Model System to Screen for Inhibitors of Iron Uptake
2672Schreiber, Stuart L.Dimeric HDAC Inhibitors
2669Vallee, Bert L.Treating Diseases Associated with Oxidative Stress through the Metalothioneine System
2658Mekalanos, John J.Compositions and Methods for the Prevention; or Treatment of Infection by Psuedomonas aeruginosa
2652Goldberg, Alfred L.Novel Candidates for Tuberculosis Therapy
2633Pizzagalli, Diego A.A Novel Screening Method for Assessment of Psychopathologic Disorders
2612Lichtman, J. W.Transgenic Mice with Fluorescently Tagged Neuronal Mitochondria as a New Tool to Study Axonal Transport
2611Lichtman, J. W.Brainbow Mice: A Technicolor Approach to map the Neuronal Circuits
2605Knipe, David M.siRNA treatment for HSV-2 infection
2580Vallee, Bert L.Endowment angiogenesis-related patents
2568Whelan, Sean P.J.Attenuated RNA Viruses for Vacine and Drug Delivery
2560Shaw, Jared T.Targeting FtsZ Activity Using Novel Antibacterials: Screening Assays, Small Molecule Hits, and Synthetic Pathways to Potent Natural Products
2559McMahon, Andrew P.Wnt1-Cre transgenic mouse model
2508Kasper, DennisPrevention of Tularemia Using an Enhanced Live Attenuated Vaccine Strain
2506Marsit, Carmen J.Detection of Invasive Bladder Cancer by DNA Hypermethylation
2505Kunes, SamProteasome-Mediated Degradation of RISC: Lead Target for Treatment of Long-Term Memory Disorders
2493Tsai, Li-HueiTargeting the Par-4 Protein as a Novel Approach in Depression Treatment
2464Schachter, Steven C.Novel Clinical Stage Treatments for Epilepsy and Pain
2438Myers, Andrew G.Natural Product Avrainvillamide and its Analogs as Targeted Anticancer Agents
2436Schreiber, Stuart L.Tubacin for Myeloma Therapy
2430Bonni, AzadRole of Chd1-APC in axonal regeneration
2419Harn, Donald AlfredA Novel Class of HIV Therapeutics: Monoclonal Antibodies that Neutralize Previously Resistant HIV Primary Isolates
2406Roth, Frederick P.Simultaneous Study of Multiple Genetic Interactions Using Multi-mutant Yeast
2393Strominger, Jack L.Novel Peptide Therapeutic for Multiple Sclerosis
2346Edwards, David A.Next Generation Pulmonary Malarial Vaccine
2314Mazitschek, RalphSpecific Targeting of Cell Division (and Cancer): Small molecule inhibitors of Eg5 Hold Potential for Enhanced Safety
2301Goldberg, Alfred L.Novel Candidates for Tuberculosis Therapy
2272Green, HowardKeratinocytes Derived from Human Embryonic Stem Cells
2230King, Randall W.A Novel Class of Proteosome Inhibitors
2212Dowling, John E.Using Zebrafish for clues about human vision loss
2196Kramnik, IgorSusceptibility to Tuberculosis 1 (sst1): Novel Target for Diagnosis and Treatment of Mycobacterium tuberculosis
2193Myers, Andrew G.Saframycin Assay
2184Tsai, Li-HueiBACE1 siRNA reduces A-Beta peptides in vivo
2170Hotamisligil, Gokhan S.Animal Model of Diabetes and Obesity: Cross-bred JNK1 KO/JNK 2 KO Mice
2144McMahon, Andrew P.Col 2A promoter Cre transgenic mice
2129Verdine, Gregory L.Mu Opioid Peptidomimetics: Lead Compounds for the Treatment of Pain
2122Keung, Wing MingTreatment of alcoholism and substance abuse using selective inhibition of alpha 2 adrenergic receptors and dopamine D2 receptors
2070Schaak, DianeToxin-Phage Bacteriocide Antibiotic and Uses Thereof
2060Schreiber, Stuart L.Anti-Mitotic Eg5 Inhibitors for Treatment of Cancer and Inflammatory Disease
1917Schreiber, Stuart L.HDAC Inhibitors
1903Coen, Donald M.A Sensitive Assay to Identify Inhibitors of HSV DNA Polymerase
1846Strominger, Jack L.Novel Peptide Therapeutic for Multiple Sclerosis
1793Ho, I ChengA Novel Class of Phospholipase A2 Preferentially Expressed in Th2 Cells
1776Munger, KarlMethods to Regulate the Duration of Th2 Activation
1742Jones, Alun G.Next Generation Diagnostics for Breast Cancer, Prostate Cancer, and Melanoma
1740Rubin, Eric JosephHyperactive mutant of the Himar1 mariner transposase
1695Halperin, Jose A.Detection of Glycated CD59 for the Diagnosis of Impaired Glucose Tolerance
1675Schreiber, Stuart L.Identification and Characterization of Class II HDACs: Lead Targets for Treatment of Cancer and Neurodegenerative Diseases
1659Yuan, Zhi-MinIdentification of a Sequence Element from p53 that Signals for Mdm2-targeted Deg
1625McKeon, Frank D.Calcipressins: Lead Targets for Autoimmune, Inflammatory, and Cardiovascular Disease
1591Corey, Elias J.Direct and Practical Synthetic Route to Pseudopterosins: Important Anti-Inflammatory, Anti-Pain, and Anti-Irritant Compounds
1587David, John R.Migration Inhibitory Factor (MIF) Knockout Mouse
1575Strominger, Jack L.Valpha24JalphaQ Receptor: Lead Diagnostic and Therapeutic for Type I Diabetes
1558Harrison, Stephen C.Vaccine Compositions & Methods for Human Papilloma Virus
1554Yuan, JunyingSmall Molecule Therapeutic and Screening Assays for Drugs Active Against Chronic Neural Degenerative Diseases.
1546Knipe, David M.Drug screening tool for herpes antivirals
1502Erikson, Raymond LeoPolo-Like Kinase Polo Box: Lead Target for Cancer Therapeutics
1475Mekalanos, John J.Systematic, condition-independent identification of essential genes of microorganisms
1452Shi, ChengweiCellular Basis of Vascular-Graft Stenosis
1416Hogle, James M.Novel Chemistry and Method to make Compounds Active Against Picornaviruses
1391Melton, DouglasCell Based Assay for Discovery of Glycogen Synthase Kinase Inhibitors
1365Fett, James W.Antisense Inhibition of Angiogenin Expression in Cancer
1250Schreiber, Stuart L.Identification and Characterization of Class II HDACs: Lead Targets for Treatment of Cancer and Neurodegenerative Diseases
1248Wessling-Resnick, MarianneSFT: An Iron Transport Protein
1229Howley, Peter M.Gene Therapy For Papillomavirus Induced Cervical Carcinoma
1188Wong, David T. W.A Novel Tumor Suppressor Protein and Gene
1173Coen, Donald M.High Lead Expression of Soluble CMV UL97 and Development of an Assay to Screen Inhibitors
1130Telford, Sam R.A Strain of the Ehrlichial Agent
1127Swanson, JoelLiposome- Based, Intracellular Delivery of Drugs into Phagocytes, B- and T- cells and their tumor cells.
1121Munger, KarlMethod and Kit for Evaluating Transformed Cells
1049Strominger, Jack L.NF-X1: Novel Target for Inhibition of MHC Class II Transcription and Autoimmune Disease
0951Russell, MaryMediators of Chronic Allograft Rejection and DNA Molecules Encoding Them
0806Essex, Myron EDeglycosylating gp120
0692Folkman, M. JudahPurification of a Smooth Muscle Cell Mitogen from Beta Tumor Cell Conditioned Me
0669Desrosiers, Ronald C.Primate Lentivirus Vaccine
0641Neutra, Marian R.Hydroxapatite -Antigen Conjugates & Methods for Generating A Poly-IG Immune Resp
0510Ribeiro, JoseVasodilatory and Immune Suppressant Peptides (formerly Salivary Gland of Flies)