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Therapeutics/Vaccines

AVAILABLE TECHNOLOGIES

Results: 80
Case # Lead Inventor Title
3430Ritter, TobiasNovel pain therapeutics to improve tolerance and activity
3391Mooney, David J.On-demand and Reversible Drug Release by External Cue
3358Corey, Elias J.Novel Antiangiogenic Agents Inspired by Cortistatin A: Next generation therapeutics for macular degeneration and cancer
3289Hu, GuofuUse of neamine for treating prostate cancer
3277Haigis, Marcia C.Inhibition of Sirt4 for treatment of obesity and enhancing fat metabolism
3133Harrison, Stephen C.A fusion intermediate state of HIV-1 gp41, targeted by broadly neutralizing antibodies, for purposes of vaccination
3094Cepko, Constance L.Protection of cone cells by HDAC4 mediated Hif1alpha activation in normal and diseased retinas
3079Auguste, Debra T.pH-triggered drug delivery
3076Yuan, JunyingSmall molecule regulators of autophagy identified by an image-based high throughput screen
2997Lory, StephenSmall-molecule inhibitors of Chlamydia cell growth
2959Clardy, Jon C.A potent antifungal agent from a Streptomycete
2954Schreiber, Stuart L.Non-ATP competitive Inhibitors of Aurora Kinases: Selective and Potent Cancer Treatment
2886DiRienzo, Albert G.Novel and Efficient Algorithm for Analyzing Large Genotypic and Phenotypic Data Sets in Clinical Trials
2868Schreiber, Stuart L.Novel Urazole Epoxyquinol Inhibitors of Hepatitis C Virus Replication
2858Desrosiers, Ronald C.AIDS vaccine using gamma-2 herpesvirus as a vector to express lentiviral (AIDS virus) genes
2785Schreiber, Stuart L.SMERs: Small Molecule Enhancers for Treatment of Cancer and Neurodegenerative Diseases
2715Whitesides, George M.Antibody purification
2672Schreiber, Stuart L.Dimeric HDAC Inhibitors
2669Vallee, Bert L.Treating Diseases Associated with Oxidative Stress through the Metalothioneine System
2652Goldberg, Alfred L.Novel Candidates for Tuberculosis Therapy
2580Vallee, Bert L.Endowment angiogenesis-related patents
2560Shaw, Jared T.Targeting FtsZ Activity Using Novel Antibacterials: Screening Assays, Small Molecule Hits, and Synthetic Pathways to Potent Natural Products
2508Kasper, DennisPrevention of Tularemia Using an Enhanced Live Attenuated Vaccine Strain
2493Tsai, Li-HueiTargeting the Par-4 Protein as a Novel Approach in Depression Treatment
2464Schachter, Steven C.Novel Clinical Stage Treatments for Epilepsy and Pain
2438Myers, Andrew G.Natural Product Avrainvillamide and its Analogs as Targeted Anticancer Agents
2436Schreiber, Stuart L.Tubacin for Myeloma Therapy
2430Bonni, AzadRole of Chd1-APC in axonal regeneration
2419Harn, Donald AlfredA Novel Class of HIV Therapeutics: Monoclonal Antibodies that Neutralize Previously Resistant HIV Primary Isolates
2393Strominger, Jack L.Novel Peptide Therapeutic for Multiple Sclerosis
2384Nibert, Max L.Determination of Intracellular Protein-Protein Interactions
2346Edwards, David A.Next Generation Pulmonary Malarial Vaccine
2314Mazitschek, RalphSpecific Targeting of Cell Division (and Cancer): Small molecule inhibitors of Eg5 Hold Potential for Enhanced Safety
2301Goldberg, Alfred L.Novel Candidates for Tuberculosis Therapy
2230King, Randall W.A Novel Class of Proteosome Inhibitors
2187Collier, R. JohnDual-activity anthrax vaccine
2184Tsai, Li-HueiBACE1 siRNA reduces A-Beta peptides in vivo
2171Mashimo, HiroshiManipulating Stem Cells for Repair and Drug Delivery at Various Anatomic Sites
2163Liu, David R.In Vivo Evolution of an RNA-Based Transcriptional Activator
2129Verdine, Gregory L.Mu Opioid Peptidomimetics: Lead Compounds for the Treatment of Pain
2122Keung, Wing MingTreatment of alcoholism and substance abuse using selective inhibition of alpha 2 adrenergic receptors and dopamine D2 receptors
2070Schaak, DianeToxin-Phage Bacteriocide Antibiotic and Uses Thereof
1917Schreiber, Stuart L.HDAC Inhibitors
1911Wagner, GerhardTreeDock protein docking software
1872Kirschner, Marc W.Targeting FtsZ Activity Using Novel Antibacterials: Screening Assays, Small Molecule Hits, and Synthetic Pathways to Potent Natural Products
1846Strominger, Jack L.Novel Peptide Therapeutic for Multiple Sclerosis
1836Rando, Robert R.Aminoglycosides Scaffolding Targeting Antibiotic-Resistant Bacteria
1834Weitz, David A.Method of Creating Self-Assembled, Selectively-Permeable Colloidosome Structures
1781Walsh, Christopher T.Techniques for high yield synthesis of macrocyclic compounds
1742Jones, Alun G.Next Generation Diagnostics for Breast Cancer, Prostate Cancer, and Melanoma
1659Yuan, Zhi-MinIdentification of a Sequence Element from p53 that Signals for Mdm2-targeted Deg
1657Yuan, JunyingDrug candidate for neurological stroke and septic shock
1633Schreiber, Stuart L.Small Molecule Arrays: A New Forefront in Drug Discovery
1625McKeon, Frank D.Calcipressins: Lead Targets for Autoimmune, Inflammatory, and Cardiovascular Disease
1613Coen, Donald M.Inhibitors of Protein-Processivity Factor
1603Falchuk, Kenneth H.Bilins as anticancer agents
1591Corey, Elias J.Direct and Practical Synthetic Route to Pseudopterosins: Important Anti-Inflammatory, Anti-Pain, and Anti-Irritant Compounds
1558Harrison, Stephen C.Vaccine Compositions & Methods for Human Papilloma Virus
1554Yuan, JunyingSmall Molecule Therapeutic and Screening Assays for Drugs Active Against Chronic Neural Degenerative Diseases.
1487Schreiber, Stuart L.High-Throughput Synthetic Platform for Natural Product Analog Libraries
1486Howley, Peter M.Compositions and Methods for Treating Papillomavirus-Infected Cells
1472Verdine, Gregory L.Synthesis of Compounds with Peptide Characteristics
1416Hogle, James M.Novel Chemistry and Method to make Compounds Active Against Picornaviruses
1372Whitman, Malcolm R.Methods and Reagents for Modulating TGF-beta Superfamily Signalling
1365Fett, James W.Antisense Inhibition of Angiogenin Expression in Cancer
1329Beverley, Stephen M.New Delivery Device for Protein Therapeutics and Vaccines
1275Ptashne, MarkSmall Molecule Transcriptional Activators: Lead Agents for Gene Therapy
1250Schreiber, Stuart L.Identification and Characterization of Class II HDACs: Lead Targets for Treatment of Cancer and Neurodegenerative Diseases
1216Knipe, David M.Herpesvirus Antiviral Drug Screen
1127Swanson, JoelLiposome- Based, Intracellular Delivery of Drugs into Phagocytes, B- and T- cells and their tumor cells.
1119Leder, PhilipEotaxin: an Eosinophil Chemoattractant
1034Mekalanos, John J.Genetically Attenuated Microbial Vaccines
0898Halperin, Jose A.Methods for Treating Arteriosclerosis
0862Leder, PhilipUse of Cytokine IP-10 as an Anti-Tumor Agent
0806Essex, Myron EDeglycosylating gp120
0699Goldberg, Alfred L.Inhibition of ubiquitination or proteasome activity to treat muscle wasting.
0692Folkman, M. JudahPurification of a Smooth Muscle Cell Mitogen from Beta Tumor Cell Conditioned Me
0669Desrosiers, Ronald C.Primate Lentivirus Vaccine
0641Neutra, Marian R.Hydroxapatite -Antigen Conjugates & Methods for Generating A Poly-IG Immune Resp
0510Ribeiro, JoseVasodilatory and Immune Suppressant Peptides (formerly Salivary Gland of Flies)