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Maryanne Fenerjian
Director of Technology Transfer Policy
Displaying: 1 - 9 of 9 Results
Production and uses of polymerase colony ("polony") arrays
The invention provides methods for rapid fabrication and use of replicable, high-density nucleic acid arrays. Array features are produced through amplification on a support matrix of nucleic acid templates of interest. A significant advance over…
Investigators
- George M. Church
- Robi D. Mitra
Surface-bound double-stranded DNA protein arrays
Developed at Harvard Medical School, this invention provides nucleic acid arrays specifically designed for the assay of DNA-dependent protein:protein binding and/or physical interactions between proteins and nucleic acid molecules. Intermolecular…
Investigators
- George M. Church
- Martha L. Bulyk
AlignAce motif searching software
Developed by genomics researchers at Harvard Medical School, AlignAce employs an algorithm that scans non-coding nucleic acid sequences at high resolution for motifs that occur with non-random frequency. This algorithm is built into a multi-level…
Investigators
- George M. Church
- Jason Hughes
- Frederick P. Roth
Time and concentration warping software for RNA and protein expression data
The predominant strategies for drug discovery today employ high-throughput screens and microarray-based methods that generate large data sets. Increasingly, these techniques are being used to study biological processes as a function of time and/or…
Investigators
- George M. Church
- John D. Aach
MicroArray spot LINEar regression (MASLINER) software
Signal intensities between samples on a microarrary typically vary by as much as three to four orders of magnitude, frustrating efforts at comparative analysis of samples assayed in parallel. At any given laser power or photomultiplier tube gain…
Investigators
- George M. Church
- John D. Aach
- Aimee Dudley
- Martin A. Steffen
Bead-based polymerase colony microarrays and nucleic acid sequencing ("Polony-FISSEQ Beads")
Foundational work of Dr. George Church has enabled the production and use of replicable arrays of polymerase-amplified nucleic acid colonies (so-called "polonies") on semisolid support matrices (see Harvard Case #1438). The present invention extends…
Investigators
- George M. Church
- Jay A. Shendure
- Gregory J. Porreca
- Jun Zhu
Modular conditional knockout: Precise temporal control of protein degradation in living cells
Polyubiquitinated proteins in eukaryotes are directed to the proteasome for degradation. It is generally accepted that proteasome-mediated proteolysis depends strictly upon ubiquitination, as disruption of that process has been observed to halt…
Investigators
- George M. Church
- Daniel M. Janse
Enhanced fidelity of sub-nanogram amplification
The importance of nucleic acid amplification from trace amounts of biological sample has increased with the expansion of genomic sequencing in various clinical and research-oriented applications. This invention characterizes techniques to reduce…
Investigators
- George M. Church
- Kun Zhang
Oligopaints as a means for marking chromosomes with superior resolution and labeling functionality
Oligopaints could provide a means for marking chromosomes with superior resolution and labeling functionality than currently commercially available chromosome paint alternatives. In addition, the technology may be applied to any organism for which…
Investigators
- Chao-ting Wu
- George M. Church
- Benjamin Richard Williams