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Reproducible Individual Brain Organoids

The human brain is a highly complex organ comprised of a variety of cell types and that are largely generated during embryonic development. While this process is invariable in vivo, it is unclear if this can be recapitulated outside of the embryo.…

Investigators

  • Paola Arlotta

Cyborg organoids with fully integrated nanoelectronics

Researchers from the Liu lab at Harvard have grown organoids with fully integrated sensors that grow with the developing cells, giving them the unique ability to study the early stages of organ development. Organoids are 3D clusters of cells that…

Investigators

  • Jia Liu
  • Kewang Nan
  • Qiang Li

Polymeric material for dentin restoration

David Mooney’s lab has demonstrated the use of triacrylates TMPTA and PETA as tools for the repair of dental tissues. They found that dental pulp stem cells (DPSCs) adhered to these triacrylate polymers, which had been cured by visible light, and…

Investigators

  • David Mooney

3D-brain organoids: Enabling discovery through patient-derived brain organoids

The Arlotta team is developing a 3D brain organoid platform, which makes it possible to study aspects of human brain development and neurodevelopmental disorders in a format amenable to large-scale production and genetic engineering.These organoids…

Investigators

  • Paola Arlotta
  • Giorgia Quadrato

Photostick: Physical isolation of single cells from tissue, for further propagation and single cell sequencing and omics

Photostick enables the physical selection of single cells from large populations in diverse environments. The novel process entails photochemical immobilization of live cells with patterned illumination, followed by removal of unwanted cells with…

Investigators

  • Adam Cohen
  • Miao-Ping Chien

A system for in vivo generation of protective CD8+ T lymphocytes and other cells of hematopoietic origin

Differentiated CD8+ effector T cells mediate long-term immunity and protection against infectious diseases and cancer. Naive T cells are refractory to transduction with viral vectors without extensive ex vivo manipulations. A team of researchers at…

Investigators

  • Arlene Sharpe
  • Nicholas Haining

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