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Pattern Detection at Low Signal-To-Noise Ratio

Robust detection of patterns at low signal-to-noise ratios (SNR) is a fundamental challenge of analyzing imaging data, particularly in biological imaging. Harvard researchers have developed innovative computational algorithms for detecting and…

Investigators

  • Nancy Kleckner
  • Frederick Chang

Fast and Efficient Platform for Cell Therapy Generation

A startup from George Church's lab intends to develop cell-therapy products ready for implantation, using a platform that programs human, induced pluripotent stem cells into potentially any differentiated cell type. The team was a runner-up in the…

Investigators

  • George Church

Autophagy Enhancers for the Treatment of Neurodegeneration

An emerging startup from Junying Yuan's lab intends to develop three classes of small molecules for the treatment of neurodegenerative diseases. (Image credit: iStock.)There are currently no disease-modifying treatments available for…

Investigators

  • Junying Yuan

New insightful biomarkers for ALS and dementia

About 90% of the amyotrophic lateral sclerosis (ALS) cases are seemingly “sporadic” without a family history of disease. With hundreds of distinct variants in more than a dozen genes contributing to disease risk, it is hard to identify disease…

Investigators

  • Kevin Eggan

Method for large-scale production of differentiated neurons

INTRODUCTIONHuman pluripotent stem cells (hPSC’s) can be used to generate a wide variety of somatic cell types. In addition, they can be grown in large numbers and thus can be a tractable source for cell types that are otherwise difficult to…

Investigators

  • Lee Rubin

Continuous directed evolution of aminoacyl-tRNA synthetases to alter amino acid specificity and enhance activity

DESCRIPTION Functions of various biotherapeutics can often be enhanced by modifying individual amino acid residues. However, the current approaches rely on existing natural amino acid chemistry. Approaches that provide new chemical “handles” will…

Investigators

  • David Liu

Evolution of Sequence-Defined Highly Functionalized Nucleic Acid Polymers

DESCRIPTION Template-directed synthesis of modified DNA sequences can provide a rich source of material for generating new therapies featuring modified nucleic acid polymers. The Liu lab has previously developed pioneering methods to generate…

Investigators

  • David Liu

Modulating the Blood-Brain Barrier (BBB) to enable delivery of drugs and development of therapeutics

The blood–brain barrier (BBB) helps maintain a constant, optimal environment for neuronal function through a combination of barriers and selective transport systems that regulate the passage of wanted and unwanted molecules. While important for…

Investigators

  • Chenghua Gu

IMPDH inhibitor Mizoribine for the treatment of Tuberous Sclerosis and LAM

Results from Brendan Manning’s lab at Harvard’s School of Public Health suggests that there is potential to use Bredinin (mizoribine), a drug widely used as an immunosuppressive drug in Japan and Europe, as an anti-tuberous sclerosis complex (TSC)…

Investigators

  • Brendan Manning

Harnessing olfactory receptors to make fragrances or flavors universally appetitive

Prof. Bob Datta and his team at Harvard Medical School have discovered a new class of odorant receptors that is structurally distinct from previously known receptors. These receptors respond to a variety of innately-relevant cues, including…

Investigators

  • Sandeep Datta

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