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Displaying: 1 - 10 of 25 Results

Inhibiting Microbial Metabolism of Levodopa to Increase Availability in the CNS

Parkinson’s disease (PD) impacts 10 million people globally, with 60,000 Americans newly diagnosed every year. Levodopa remains the gold standard treatment for PD, despite limitations including side effects and peripheral metabolism. Current…

Investigators

  • Emily Balskus

Reproducible Individual Brain Organoids

The human brain is a highly complex organ comprised of a variety of cell types and that are largely generated during embryonic development. While this process is invariable in vivo, it is unclear if this can be recapitulated outside of the embryo.…

Investigators

  • Paola Arlotta

New insightful biomarkers for ALS and dementia

About 90% of the amyotrophic lateral sclerosis (ALS) cases are seemingly “sporadic” without a family history of disease. With hundreds of distinct variants in more than a dozen genes contributing to disease risk, it is hard to identify disease…

Investigators

  • Kevin Eggan

Method for large-scale production of differentiated neurons

INTRODUCTIONHuman pluripotent stem cells (hPSC’s) can be used to generate a wide variety of somatic cell types. In addition, they can be grown in large numbers and thus can be a tractable source for cell types that are otherwise difficult to…

Investigators

  • Lee Rubin

Continuous directed evolution of aminoacyl-tRNA synthetases to alter amino acid specificity and enhance activity

DESCRIPTION Functions of various biotherapeutics can often be enhanced by modifying individual amino acid residues. However, the current approaches rely on existing natural amino acid chemistry. Approaches that provide new chemical “handles” will…

Investigators

  • David Liu

Evolution of Sequence-Defined Highly Functionalized Nucleic Acid Polymers

DESCRIPTION Template-directed synthesis of modified DNA sequences can provide a rich source of material for generating new therapies featuring modified nucleic acid polymers. The Liu lab has previously developed pioneering methods to generate…

Investigators

  • David Liu

Modulating the Blood-Brain Barrier (BBB) to enable delivery of drugs and development of therapeutics

The blood–brain barrier (BBB) helps maintain a constant, optimal environment for neuronal function through a combination of barriers and selective transport systems that regulate the passage of wanted and unwanted molecules. While important for…

Investigators

  • Chenghua Gu

3D-brain organoids: Enabling discovery through patient-derived brain organoids

The Arlotta team is developing a 3D brain organoid platform, which makes it possible to study aspects of human brain development and neurodevelopmental disorders in a format amenable to large-scale production and genetic engineering.These organoids…

Investigators

  • Paola Arlotta
  • Giorgia Quadrato

FlicR: A bright and fast red fluorescent protein voltage indicator that reports neuronal activity

Fluorescent-protein-based voltage indicators enable imaging of the electrical activity of many genetically targeted neurons with high spatial and temporal resolution. FlicR is a new bright red fluorescent protein-based voltage indicator that has…

Investigators

  • Adam Cohen

Liquid biopsy-based predictive platform for early cancer detection and drug discovery

Recognition and management of individuals susceptible to disease are critical for patient care. However, identification of these patients is very challenging, especially in oncology. Dr. Peter Park and his group at the Department of Biomedical…

Investigators

  • Peter Park

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