Browse Technologies
Browse Technologies
Technology Keyword Search
Diagnostics/Biomarkers
Search Results
Displaying: 1 - 10 of 19 Results
Isolating live cells after high-throughput, long-term, time-lapse microscopy
Researchers led by Johan Paulsson have engineered a high-throughput microfluidic device for multigenerational culturing, imaging, and tracking of single-cell lineages. The platform is highly customizable and is compatible with many cell types,…
DBD
- Irit Ben-Chelouche
Investigators
- Johan Paulsson
Rapid point-of-care COVID-19 detection assay by RT-LAMP
The current SARS-CoV-2 pandemic has created an urgent need for rapid point-of-care diagnostic tools. Many of these tests are being developed and are achieving FDA approval. In the face of a sweeping pandemic, assays should require no specialized…
DBD
- Grant Zimmermann
Investigators
- Constance Cepko
Machine learning to accelerate diagnostics and therapeutics for COVID-19
The COVID-19 pandemic demands a rapid response of science, diagnostics, and therapeutics. Debora Marks’ lab at Harvard Medical School aims to accelerate those efforts using predictive models of the SARS-CoV2-19 sequences and 3D structures. The lab’s…
DBD
- Irit Ben-Chelouche
Investigators
- Debora Marks
Hyperpolarized contrast agents for MRI with long relaxation times
When the nuclear orientation of a material is hyperpolarized by techniques such as dynamic nuclear polarization, these materials can function as extremely effective contrast agents for magnetic resonance imaging (MRI). In most cases, however, the…
Investigators
- Charles Marcus
Liquid biopsy-based predictive platform for early cancer detection and drug discovery
Recognition and management of individuals susceptible to disease are critical for patient care. However, identification of these patients is very challenging, especially in oncology. Dr. Peter Park and his group at the Department of Biomedical…
DBD
- Irit Ben-Chelouche
Investigators
- Peter Park
A novel and effective technology for target-based screening
Target-based screening allows for rapid identification of ligands for an increasing number of macromolecular targets and is commonly used in drug discovery.The present invention uses interaction-dependent PCR (IDPCR) to selectively identify…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
- Christoph Dumelin
- David Gorin
- Lynn McGregor
Highly specific chemical detection using NMR at low magnetic fields
NMR often does not have sufficient resolution to distinguish between chemicals with related or similar structures in the presence of a large background, which leads to poor chemical specificity. The NMR spectra of complex chemical mixtures may…
Investigators
- Ronald Walsworth
- Matthew Rosen
- Stephen DeVience
Photostick: Physical isolation of single cells from tissue, for further propagation and single cell sequencing and omics
Photostick enables the physical selection of single cells from large populations in diverse environments. The novel process entails photochemical immobilization of live cells with patterned illumination, followed by removal of unwanted cells with…
DBD
- Yelena Bisharyan
Investigators
- Adam Cohen
- Miao-Ping Chien
Genomic Analysis Tool Box
Cancer genomes frequently harbor high mutation rates, complex structural variations, and are characterized by genome instability. Detailed understanding of these characteristics of the cancer genome is necessary for pinpointing the cause of tumor…
DBD
- Irit Ben-Chelouche
Investigators
- Peter Park
The next generation of cholesterol screening - A personalized diagnostic index for the improved assessment of cardiovascular risk using a novel method for the measurement of lipoprotein subtypes
OpportunityThis program offers the next generation of cholesterol screening. In 2013, 96 million visits to doctors' offices in the US included a cholesterol test.Problem/Unmet needCurrent practice of measuring total HDL level in serum does not…
DBD
- Grant Zimmermann
Investigators
- Frank Sacks