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Digital DNA Storage System

A startup emerging from George Church's lab intends to leverage new enzymatic approaches to develop a cost-effective digital DNA storage system. (Image credit: Shutterstock/Chornyi Serhii.)The volume of global digital information is growing…

Investigators

  • George Church

Method for large-scale production of differentiated neurons

INTRODUCTIONHuman pluripotent stem cells (hPSC’s) can be used to generate a wide variety of somatic cell types. In addition, they can be grown in large numbers and thus can be a tractable source for cell types that are otherwise difficult to…

Investigators

  • Lee Rubin

SIM-PAL: proteome wide identification of small molecule binding sites

Precise target identification for small molecules is an important and essential step in drug development. Despite its importance, there are very few unbiased, proteome-wide approaches aimed at identifying binding partners for small molecules. In…

Investigators

  • Christina Woo

Polycystic Kidney Disease: Mechanistic Dissection and Discovering Precision Therapeutic Targets

Autosomal-dominant polycystic kidney disease (ADPKD) is a life-threatening monogenic disease that affects nearly 1 million people in the U.S. alone. ADPKD represents a very large unmet medical need, currently without remedy. It is characterized by…

Investigators

  • Adrian Salic

3D-brain organoids: Enabling discovery through patient-derived brain organoids

The Arlotta team is developing a 3D brain organoid platform, which makes it possible to study aspects of human brain development and neurodevelopmental disorders in a format amenable to large-scale production and genetic engineering.These organoids…

Investigators

  • Paola Arlotta
  • Giorgia Quadrato

Photostick: Physical isolation of single cells from tissue, for further propagation and single cell sequencing and omics

Photostick enables the physical selection of single cells from large populations in diverse environments. The novel process entails photochemical immobilization of live cells with patterned illumination, followed by removal of unwanted cells with…

Investigators

  • Adam Cohen
  • Miao-Ping Chien

Immunology and Computational Biology Partnership

Professors Diane Mathis and Christophe Benoist at Harvard Medical School, together with other world-renowned immunologists and computational biologists from multiple research institutions, have created the Immunological Genome Project – Immgen…

Investigators

  • Diane Mathis
  • Christophe Benoist

A drug discovery platform using novel labeled uridine analogs contribute to molecular biology research

This invention consists of novel 5-amino deoxyribouridine analogs. The analogs are labeled with a radioactive or fluorescent moiety and incorporated into nucleic acid by PCR for use in genomic research applications. One assay design involves a…

Investigators

  • Gregory Verdine
  • Michael Storek

Directed evolution of proteins and nucleic acids using nonhomologous random recombination

The nonhomologous random recombination (NRR) method allows portions of nucleic acids to be recombined at sites where there is little or no sequence homology. This increases the frequency at which novel sequences are generated, allowing a more…

Investigators

  • David Liu
  • Joshua Bittker

Enhanced fidelity of sub-nanogram amplification

The importance of nucleic acid amplification from trace amounts of biological sample has increased with the expansion of genomic sequencing in various clinical and research-oriented applications. This invention characterizes techniques to reduce…

Investigators

  • George Church
  • Kun Zhang

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