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Displaying: 1 - 10 of 23 Results
Continuous Evolution (PACE) of Botulinum Neurotoxins with Reprogrammed Substrate Specificity for Intracellular Protease Therapy
Biomacromolecule-based therapies are of keen interest to the pharmaceutical industry because macromolecules engage in highly specific interactions in biological systems compared to traditional small molecules. Despite their success, macromolecular…
Investigators
- David Liu
DNA Destruction Through Novel and Adaptable Enzymes
Bacteria in mixed populations compete for resources and have several strategies on surviving and dominating other bacterial species. One method employs the injection of lethal effectors into adjacent cells. These effectors can disrupt cell membranes…
Investigators
- Karine Gibbs
Isolating live cells after high-throughput, long-term, time-lapse microscopy
Researchers led by Johan Paulsson have engineered a high-throughput microfluidic device for multigenerational culturing, imaging, and tracking of single-cell lineages. The platform is highly customizable and is compatible with many cell types,…
Investigators
- Johan Paulsson
Cancer Treatment through TRPA1 antagonism
Researchers in Joan Brugge’s lab have identified a new cancer therapeutic target in the ion channel transient receptor potential ankyrin 1 (TRPA1). The lab is seeking collaborations with industry partners to expand on these exciting findings.The…
Investigators
- Joan Brugge
Exo-site Enzyme Inhibitor Discovery Platform for Oncology Therapeutics
A startup emerging from David Liu's lab intends to commercialize a small-molecule enzyme inhibitor discovery platform to generate more potent drugs with higher specificity. (Image credit: Rose Lincoln/Harvard Staff Photographer.)Off-target drug…
Investigators
- David Liu
Continuous directed evolution of aminoacyl-tRNA synthetases to alter amino acid specificity and enhance activity
DESCRIPTION Functions of various biotherapeutics can often be enhanced by modifying individual amino acid residues. However, the current approaches rely on existing natural amino acid chemistry. Approaches that provide new chemical “handles” will…
Investigators
- David Liu
Evolution of Sequence-Defined Highly Functionalized Nucleic Acid Polymers
DESCRIPTION Template-directed synthesis of modified DNA sequences can provide a rich source of material for generating new therapies featuring modified nucleic acid polymers. The Liu lab has previously developed pioneering methods to generate…
Investigators
- David Liu
Universal Early Cancer Diagnostic
DescriptionThe methylation of DNA is an important epigenetic modification that regulates gene expression. A variety of disease states, cancer in particular, are thought to originate from defects in this process leading to changes in the DNA…
Investigators
- Alexander Meissner
Oral delivery of biologics
Biologics are used to treat a variety of chronic diseases including diabetes and arthritis. Not surprisingly, they command a large share of the therapeutics market. Moreover, a large number of therapeutic proteins are currently in clinical…
Investigators
- Samir Mitragotri
Anti-cancer Therapeutic Strategy Targeting Ammonium Metabolism
Cancer has long been recognized as a disease of altered cellular metabolism as cancer cells have an abnormally high demand for nutrients to support their growth and proliferation. However, targeting cancer cell metabolism has not been seriously…
Investigators
- Marcia Haigis
- Jessica Spinelli