Harvard Office of Technology Development

Isolating live cells after high-throughput, long-term, time-lapse microscopy

Researchers led by Johan Paulsson have engineered a high-throughput microfluidic device for multigenerational culturing, imaging, and tracking of single-cell lineages. The platform is highly customizable and is compatible with many cell types,…

Investigators

Johan Paulsson

Microfluidic trapping chip for culture and assay of cell clusters

Diabetes has a massive disease burden worldwide. Despite advances in care, patient morbidity and mortality remain high and there is a need to develop new therapies that improve clinical outcomes. In healthy individuals, beta cells found within…

Investigators

Kevin Parker
Aaron Glieberman
John Ferrier
John Zimmerman

Printing Microparticles for Drug Delivery

A startup emerging from Jennifer Lewis' lab intends to commercialize a technology platform that can produce microdroplets of highly viscous fluids, with applications in drug formulation and delivery. (Image courtesy of the Lewis Lab.)Droplet-based…

Investigators

Jennifer Lewis

Regenerative Cell Therapy for Skeletal Muscle Disorders

A startup emerging from Lee Rubin's lab aims to provide a long-term cell therapy regenerative solution for conditions that result in reduced or improper skeletal muscle regeneration. (Image credit: B.D. Colen/Harvard Staff.)Cell therapies hold…

Investigators

Lee Rubin

Fast and Efficient Platform for Cell Therapy Generation

A startup from George Church's lab intends to develop cell-therapy products ready for implantation, using a platform that programs human, induced pluripotent stem cells into potentially any differentiated cell type. The team was a runner-up in the…

Investigators

George Church

Mechanically-induced regeneration

Skeletal muscle and satellite cells are sensitive to biophysical and microenvironmental cues, and there is evidence that physical manipulation of damaged muscle may promote recovery. David Mooney’s lab has used biphasic ferrogel scaffolds to create…

Investigators

David Mooney

Polymeric material for dentin restoration

David Mooney’s lab has demonstrated the use of triacrylates TMPTA and PETA as tools for the repair of dental tissues. They found that dental pulp stem cells (DPSCs) adhered to these triacrylate polymers, which had been cured by visible light, and…

Investigators

David Mooney

In vivo gene editing in dystrophic muscle

Duchenne Muscular Dystrophy (DMD) is a debilitating disease caused by the absence of dystrophin, a protein expressed in muscle fibers. This X-linked disease affects 1 in 3000/4000 male births and average life expectancy is 26. While improvements in…

Investigators

Amy Wagers

3D-brain organoids: Enabling discovery through patient-derived brain organoids

The Arlotta team is developing a 3D brain organoid platform, which makes it possible to study aspects of human brain development and neurodevelopmental disorders in a format amenable to large-scale production and genetic engineering.These organoids…

Investigators

Paola Arlotta
Giorgia Quadrato

Materials presenting Notch signaling molecules to control cell behavior

This technology has direct application to stem cell therapy, regenerative medicine, and tissue engineering in vivo (in the patient) and in vitro (in tissue culture dish). -In vitro stem cell manipulation- Using this method of introducing Notch…

Investigators

David Mooney
Lan Cao
Kamal Bouhadir