
Browse Technologies
Keyword Search
Search Results
Displaying: 1 - 10 of 19 Results
Isolating live cells after high-throughput, long-term, time-lapse microscopy
Researchers led by Johan Paulsson have engineered a high-throughput microfluidic device for multigenerational culturing, imaging, and tracking of single-cell lineages. The platform is highly customizable and is compatible with many cell types,…
Investigators
- Johan Paulsson
Microfluidic trapping chip for culture and assay of cell clusters
Diabetes has a massive disease burden worldwide. Despite advances in care, patient morbidity and mortality remain high and there is a need to develop new therapies that improve clinical outcomes. In healthy individuals, beta cells found within…
Investigators
- Kevin Parker
- Aaron Glieberman
- John Ferrier
- John Zimmerman
Printing Microparticles for Drug Delivery
A startup emerging from Jennifer Lewis' lab intends to commercialize a technology platform that can produce microdroplets of highly viscous fluids, with applications in drug formulation and delivery. (Image courtesy of the Lewis Lab.)Droplet-based…
Investigators
- Jennifer Lewis
Regenerative Cell Therapy for Skeletal Muscle Disorders
A startup emerging from Lee Rubin's lab aims to provide a long-term cell therapy regenerative solution for conditions that result in reduced or improper skeletal muscle regeneration. (Image credit: B.D. Colen/Harvard Staff.)Cell therapies hold…
Investigators
- Lee Rubin
Fast and Efficient Platform for Cell Therapy Generation
A startup from George Church's lab intends to develop cell-therapy products ready for implantation, using a platform that programs human, induced pluripotent stem cells into potentially any differentiated cell type. The team was a runner-up in the…
Investigators
- George Church
Mechanically-induced regeneration
Skeletal muscle and satellite cells are sensitive to biophysical and microenvironmental cues, and there is evidence that physical manipulation of damaged muscle may promote recovery. David Mooney’s lab has used biphasic ferrogel scaffolds to create…
Investigators
- David Mooney
Polymeric material for dentin restoration
David Mooney’s lab has demonstrated the use of triacrylates TMPTA and PETA as tools for the repair of dental tissues. They found that dental pulp stem cells (DPSCs) adhered to these triacrylate polymers, which had been cured by visible light, and…
Investigators
- David Mooney
In vivo gene editing in dystrophic muscle
Duchenne Muscular Dystrophy (DMD) is a debilitating disease caused by the absence of dystrophin, a protein expressed in muscle fibers. This X-linked disease affects 1 in 3000/4000 male births and average life expectancy is 26. While improvements in…
Investigators
- Amy Wagers
3D-brain organoids: Enabling discovery through patient-derived brain organoids
The Arlotta team is developing a 3D brain organoid platform, which makes it possible to study aspects of human brain development and neurodevelopmental disorders in a format amenable to large-scale production and genetic engineering.These organoids…
Investigators
- Paola Arlotta
- Giorgia Quadrato
Materials presenting Notch signaling molecules to control cell behavior
This technology has direct application to stem cell therapy, regenerative medicine, and tissue engineering in vivo (in the patient) and in vitro (in tissue culture dish). -In vitro stem cell manipulation- Using this method of introducing Notch…
Investigators
- David Mooney
- Lan Cao
- Kamal Bouhadir