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Stem Cells/Regenerative Medicine
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Displaying: 1 - 10 of 19 Results
Isolating live cells after high-throughput, long-term, time-lapse microscopy
Researchers led by Johan Paulsson have engineered a high-throughput microfluidic device for multigenerational culturing, imaging, and tracking of single-cell lineages. The platform is highly customizable and is compatible with many cell types,…
DBD
- Irit Ben-Chelouche
Investigators
- Johan Paulsson
Printing Microparticles for Drug Delivery
A startup emerging from Jennifer Lewis' lab intends to commercialize a technology platform that can produce microdroplets of highly viscous fluids, with applications in drug formulation and delivery. (Image courtesy of the Lewis Lab.)Droplet-based…
DBD
- Christopher Petty
Investigators
- Jennifer Lewis
Regenerative Cell Therapy for Skeletal Muscle Disorders
A startup emerging from Lee Rubin's lab aims to provide a long-term cell therapy regenerative solution for conditions that result in reduced or improper skeletal muscle regeneration. (Image credit: B.D. Colen/Harvard Staff.)Cell therapies hold…
DBD
- Vivian Berlin
Investigators
- Lee Rubin
Mechanically-induced regeneration
Skeletal muscle and satellite cells are sensitive to biophysical and microenvironmental cues, and there is evidence that physical manipulation of damaged muscle may promote recovery. David Mooney’s lab has used biphasic ferrogel scaffolds to create…
Investigators
- David Mooney
Polymeric material for dentin restoration
David Mooney’s lab has demonstrated the use of triacrylates TMPTA and PETA as tools for the repair of dental tissues. They found that dental pulp stem cells (DPSCs) adhered to these triacrylate polymers, which had been cured by visible light, and…
Investigators
- David Mooney
3D-brain organoids: Enabling discovery through patient-derived brain organoids
The Arlotta team is developing a 3D brain organoid platform, which makes it possible to study aspects of human brain development and neurodevelopmental disorders in a format amenable to large-scale production and genetic engineering.These organoids…
DBD
- Yelena Bisharyan
Investigators
- Paola Arlotta
- Giorgia Quadrato
"MoleProbe": A real-time molecular diagnostic device
The invention is a novel engineering method for generation of freestanding 2-D and 3-D tissue structures. Biopolymers (proteins, carbohydrates, lipids, nucleic acids or combinations thereof) are deposited onto a transitional polymer surface with a…
Investigators
- Kevin Parker
In vitro models and method of treatment for amyotrophic lateral sclerosis (ALS)
It has been impossible to isolate viable human motor neurons from patients or from postmortem samples to investigate the mechanisms leading to neural degeneration in ALS. A potential solution is to use embryonic stem cells (ESC) as a renewable…
DBD
- Vivian Berlin
Investigators
- Kevin Eggan
- Francesco Di Giorgio
Using (-)-indolactam V to induce differentiation of human and mouse embryonic stem cells into pancreatic lineage
• ILV can be used alone, or in combination with growth factors, to direct differentiation of ESCs into pancreatic specification. ILV is effective on human ESC lines and mouse ESC lines. • ILV is effective on human ESC lines HUES 2, 4 and 8. After 4…
DBD
- Vivian Berlin
Investigators
- Douglas Melton
- Shuibing Chen
- Malgorzata Borowiak
- Julia Fox
- Stuart Schreiber
- Lee Peng
- Lee Rubin
- Kelvin Lam
- Lance Davidow
Vertical silicon nanowires as a universal platform for highly efficient delivery of bioactive molecules into living cells
This platform consists of an array of surface-modified vertical silicon nanowires that have been chemically grown or etched on a wafer and to which virtually any kind of bioactive species (drug, protein, nucleic acid, nanoparticles) may be attached…
DBD
- Christopher Petty
Investigators
- Hongkun Park
- EunGyeong Yang
- JinSeok Lee
- Alexander Shalek
- Myung-Han Yoon
- Jacob Robinson
- Amy Sutton
- Marsela Jorgolli