Harvard Office of Technology Development

Isolating live cells after high-throughput, long-term, time-lapse microscopy

Researchers led by Johan Paulsson have engineered a high-throughput microfluidic device for multigenerational culturing, imaging, and tracking of single-cell lineages. The platform is highly customizable and is compatible with many cell types,…

Investigators

Johan Paulsson

Printing Microparticles for Drug Delivery

A startup emerging from Jennifer Lewis' lab intends to commercialize a technology platform that can produce microdroplets of highly viscous fluids, with applications in drug formulation and delivery. (Image courtesy of the Lewis Lab.)Droplet-based…

Investigators

Jennifer Lewis

Regenerative Cell Therapy for Skeletal Muscle Disorders

A startup emerging from Lee Rubin's lab aims to provide a long-term cell therapy regenerative solution for conditions that result in reduced or improper skeletal muscle regeneration. (Image credit: B.D. Colen/Harvard Staff.)Cell therapies hold…

Investigators

Lee Rubin

Mechanically-induced regeneration

Skeletal muscle and satellite cells are sensitive to biophysical and microenvironmental cues, and there is evidence that physical manipulation of damaged muscle may promote recovery. David Mooney’s lab has used biphasic ferrogel scaffolds to create…

Investigators

David Mooney

Polymeric material for dentin restoration

David Mooney’s lab has demonstrated the use of triacrylates TMPTA and PETA as tools for the repair of dental tissues. They found that dental pulp stem cells (DPSCs) adhered to these triacrylate polymers, which had been cured by visible light, and…

Investigators

David Mooney

In vivo gene editing in dystrophic muscle

Duchenne Muscular Dystrophy (DMD) is a debilitating disease caused by the absence of dystrophin, a protein expressed in muscle fibers. This X-linked disease affects 1 in 3000/4000 male births and average life expectancy is 26. While improvements in…

Investigators

Amy Wagers

3D-brain organoids: Enabling discovery through patient-derived brain organoids

The Arlotta team is developing a 3D brain organoid platform, which makes it possible to study aspects of human brain development and neurodevelopmental disorders in a format amenable to large-scale production and genetic engineering.These organoids…

Investigators

Paola Arlotta
Giorgia Quadrato

Vertical silicon nanowires as a universal platform for highly efficient delivery of bioactive molecules into living cells

This platform consists of an array of surface-modified vertical silicon nanowires that have been chemically grown or etched on a wafer and to which virtually any kind of bioactive species (drug, protein, nucleic acid, nanoparticles) may be attached…

Investigators

Hongkun Park
EunGyeong Yang
JinSeok Lee
Alexander Shalek
Myung-Han Yoon
Jacob Robinson
Amy Sutton
Marsela Jorgolli

In vitro models and method of treatment for amyotrophic lateral sclerosis (ALS)

It has been impossible to isolate viable human motor neurons from patients or from postmortem samples to investigate the mechanisms leading to neural degeneration in ALS. A potential solution is to use embryonic stem cells (ESC) as a renewable…

Investigators

Kevin Eggan
Francesco Di Giorgio

Using (-)-indolactam V to induce differentiation of human and mouse embryonic stem cells into pancreatic lineage

• ILV can be used alone, or in combination with growth factors, to direct differentiation of ESCs into pancreatic specification. ILV is effective on human ESC lines and mouse ESC lines. • ILV is effective on human ESC lines HUES 2, 4 and 8. After 4…

Investigators

Douglas Melton
Shuibing Chen
Malgorzata Borowiak
Julia Fox
Stuart Schreiber
Lee Peng
Lee Rubin
Kelvin Lam
Lance Davidow