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Displaying: 11 - 20 of 21 Results

Anti-cancer Therapeutic Strategy Targeting Ammonium Metabolism

Cancer has long been recognized as a disease of altered cellular metabolism as cancer cells have an abnormally high demand for nutrients to support their growth and proliferation. However, targeting cancer cell metabolism has not been seriously…

Investigators

  • Marcia Haigis
  • Jessica Spinelli

Intracellular delivery of proteins: Aurin 1.2, an efficient non-endosomal protein delivery platform

To fully realize the therapeutic potential of proteins, exogenous proteins need to access intracellular targets. Since the vast majority of proteins cannot spontaneously cross cell membranes, a range of delivery platforms have been developed. These…

Investigators

  • David Liu

Targeting spiral ganglion neurons for treatment of hearing loss

Hearing loss makes interactions with the world challenging for over 30 million people in the United States. While cochlear implants and hearing aid devices can ameliorate hearing loss, they often fail to restore the function of spiral ganglion…

Investigators

  • Lisa Goodrich

Lead compounds for the treatment of pain

The invention is a novel synthetic pathway to the generation of nonpeptidic ligands for the mu opioid class of G-protein coupled receptors. The system uses stereochemical variation and acyclic geometric stereocontrol to generate diversity among its…

Investigators

  • Gregory Verdine
  • Bryce Harrison
  • Tiffany Gierasch
  • Zhangjie Shi

Monoclonal IgE anti-ovalbumin antibody

A laboratory from the Harvard School of Public Health has developed a monoclonal Ig E mouse anti-ovalbumin. This antibody is useful as a positive control in ELISA assays used to measure the level of IgE anti-ovalbumin antibodies in mouse models of…

Investigators

  • Lester Kobzik
  • Aiyappa Palecanda

Modular conditional knockout:  Precise temporal control of protein degradation in living cells

Polyubiquitinated proteins in eukaryotes are directed to the proteasome for degradation. It is generally accepted that proteasome-mediated proteolysis depends strictly upon ubiquitination, as disruption of that process has been observed to halt…

Investigators

  • George Church
  • Daniel Janse

Small-molecule-triggered intein splicing as a universal switch for protein activation

Researchers in the laboratory of Professor David Liu have used directed evolution techniques to evolve an intein-based molecular switch that transduces binding of a small molecule into the activation of an arbitrary protein of interest. To create…

Investigators

  • David Liu
  • Allen Buskirk
  • Sun Peck

Fzd2 - novel anti-cancer therapeutic target

The role of β-catenin accumulation in the development of tumorigenicity has been well documented to date, with various mutations in β-catenin, APC, and axin genes typically to blame. Although β-catenin accumulation plays a role in hepatocellular…

Investigators

  • Gavin MacBeath
  • Taran Gujral

Synthesis of compounds with peptide characteristics

Although peptides have shown some promise in clinical trials as therapeutic agents, its success has largely been limited by several factors, including rapid degradation by peptidases, poor cell permeability, and a lack of binding specificity…

Investigators

  • Gregory Verdine
  • Milan Chytil
  • Mary Didiuk
  • Tiffany Gierasch

Anti-PLK-1 monoclonal antibody

The monoclonal antibody PLK-1 recognizes the Macrophage Receptor with Collagenous structure (MARCO). The scavenger receptors (SRs) expressed by macrophages are thought to play an important role in the immune response against bacteria by mediating…

Investigators

  • Lester Kobzik
  • Aiyappa Palecanda

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