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Displaying: 11 - 19 of 19 Results
Studying interactions between essential bacterial ABC (ATP-binding cassette) transporter MsbA and bacterial LPS to pave the way for new antibiotic discovery
Gram-negative bacteria cause multiple infectious disease and are increasingly becoming resistant to antibiotics. However, development of drugs targeting these organisms is complicated by the extreme complexity of the structure of gram-negative cell…
Investigators
- Maofu Liao
Novel Antifungal Agent
The existing suite of clinically useful antifungals is limited. While amphotericin B and nystatin have been used widely over the past 50 years, they are associated with high toxicity and negligible oral bioavailability. Harvard researchers in the…
Investigators
- Jon Clardy
Small molecule inhibitors of Zika, dengue and other flaviviruses
Currently, broadly-protective antivirals targeting flaviviruses such as Zika, Dengue and West Nile viruses, are not available. Researchers in the laboratory of Dr. Priscilla Yang have identified a group of small molecules, including a prototype…
Investigators
- Priscilla Yang
Photostick: Physical isolation of single cells from tissue, for further propagation and single cell sequencing and omics
Photostick enables the physical selection of single cells from large populations in diverse environments. The novel process entails photochemical immobilization of live cells with patterned illumination, followed by removal of unwanted cells with…
Investigators
- Adam Cohen
- Miao-Ping Chien
Environmentally Safe, First-in-Class Mosquito Sterilant
Dr. Flaminia Catteruccia from the Harvard T.H. Chan School of Public Health has discovered a biopesticide that is capable of sterilizing mosquitoes while being safe for human and environmental health. Spraying pesticides is a common method to…
Investigators
- Flaminia Catteruccia
Homozygous IKKepsilon knockout mouse as an animal model for influenza virus infection
Homozygous IKKepsilon (inhibitor of kappaB kinase epsilon) mutant mice are used as animal models for influenza virus infection. Homozygous deletion results in a complete loss of the endogenous kinase function in lung, spleen, and embryonic…
Investigators
- Thomas Maniatis
- Benjamin tenOever
Protein-based therapies using quantitatively designed proteins
A bipartite, quantitatively designed protein having two discrete ligands and a linker; one ligand having the ability to strongly bind to a particular cell, the other having the ability to affect a target only when the previous ligand binds. For many…
Investigators
- Pamela Silver
- Pablo Cironi
- David Miguez
A fusion intermediate state of HIV-1 gp41, targeted by broadly neutralizing antibodies, for purposes of vaccination
HIV infection generally induces a strong antibody response to the envelope glycoprotein, the sole antigen on the virion surface. Most of the induced antibodies are ineffective in preventing infection, however, as they are either non-neutralizing or…
Investigators
- Stephen Harrison
- Gary Frey
- Bing Chen
Small molecule inhibitors of Ebola virus entry
Background: Human cells that are susceptible to infection by pathogenic viruses express surface membrane proteins that mediate attachment and membrane fusion activity of virus glycoproteins. There are strong structural and functional similarities…
Investigators
- Dennis Kasper
- Kyungae Lee
- Tao Ren
- James Cunningham
- Kartik Chandran