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Displaying: 11 - 15 of 15 Results
Paper-supported 3D cell culture for cell and tissue-based bioassays
In this new approach, cells are cultured in 3D on a paper scaffold by adding a hydrogel precursor, as a fluid containing suspended cells, to a paper support, allowing the cell-containing fluid to distribute through the paper by capillary wicking,…
DBD
- Christopher Petty
Investigators
- George Whitesides
- Ratmir Derda
- Anna Laromaine Sague
Materials presenting Notch signaling molecules to control cell behavior
This technology has direct application to stem cell therapy, regenerative medicine, and tissue engineering in vivo (in the patient) and in vitro (in tissue culture dish). -In vitro stem cell manipulation- Using this method of introducing Notch…
Investigators
- David Mooney
- Lan Cao
- Kamal Bouhadir
Induced motor neurons (iMNs)
The team converted mouse and human fibroblasts into iMNs by the forced expression of select transcription factors. Producing motor neurons this way is much less labor intensive than having to go through the process of creating induced pluripotent…
DBD
- Vivian Berlin
Investigators
- Kevin Eggan
- Justin Ichida
- Esther Son
- Brian Wainger
- Clifford Woolf
New therapeutic pathway for autoimmune and inflammatory disorders
A recently-discovered class of T cells - T follicular regulatory (TFR) cells - controls the production of antibodies. TFR cells inhibit T follicular helper (TFH) cells, which mediate antibody production in lymph nodes. Several autoimmune diseases…
DBD
- Irit Ben-Chelouche
Investigators
- Arlene Sharpe
- Peter Sage
- Loise Francisco
Preventing Stress-Induced Greying of Hair
Loss of hair pigmentation has long been associated with stress; however, stress-related changes at the level of the somatic cell have only recently been elucidated. The hair follicle consists of two stem cell populations: epithelial-derived hair…
DBD
- Yelena Bisharyan
Investigators
- Ya-Chieh Hsu
- Bing Zhang