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Displaying: 1-10 of 118 Results
3D-brain organoids: Enabling discovery through patient-derived brain organoids
The Arlotta team is developing a 3D brain organoid platform, which makes it possible to study aspects of human brain development and…
Investigators:
Paola Arlotta
Giorgia Quadrato
Case #: 5942A drug discovery platform using novel labeled uridine analogs contribute to molecular biology research
This invention consists of novel 5-amino deoxyribouridine analogs. The analogs are labeled with a radioactive or fluorescent moiety and…
Investigators:
Gregory Verdine
Michael Storek
Case #: 1823A Fluorescence-based Reporter System Measuring Ubiquitin-dependent 26S Proteasome Activity
The 26S proteasome mediates protein degradation and has been shown to be an important therapeutic target for treating cancer,…
Investigators:
Marc Kirschner
Case #: 6585A fragment based drug discovery platform for high-throughput synthesis and screening of protein-protein inhibitors
The present invention enables generation of a large number of rigid compounds that incorporate one or more protein binding fragments in a…
Investigators:
Gerhard Wagner
Patrick Hagner
Haribabu Arthanari
Vladimir Gelev
Ricard Rodriguez-Mias
Amr Fahmy
Case #: 4717A genetically modified herpes simplex virus that has utility as a drug screening tool
Harvard Medical School researchers have developed a genetically modified herpes simplex virus that has utility as a drug screening tool. To…
Investigators:
David Knipe
Elizabeth McNamee
Travis Taylor
Case #: 1546A novel and effective technology for target-based screening
Target-based screening allows for rapid identification of ligands for an increasing number of macromolecular targets and is commonly used in…
Investigators:
David Liu
Christoph Dumelin
David Gorin
Lynn McGregor
Case #: 5368A rapid and inducible method for repressing gene function
The Struhl lab has developed a rapid and effective means to inactivate a target gene, including genes involved in essential pathways. This…
Investigators:
Kevin Struhl
Zarmik Moqtaderi
Case #: 1426A system for the continuous directed evolution of biomolecules
Researchers in the laboratory of Professor David Liu have developed a platform that enables the continuous directed evolution of…
Investigators:
David Liu
Kevin Esvelt
Jacob Carlson
Ahmed Badran
Case #: 3326A tool for the linkage and presentation of multiple protein functional domains
Recent molecular biology research is moving beyond genetics to look at protein-protein interactions and how cells interact, or communicate.…
Investigators:
James Hogle
Harmon Zuccola
David Filman
Carl Elkin
Case #: 1528A transgenic reporter system can be used for recombination-mediated modulation of gene activity in the developing mouse embryo
A transgenic reporter system consisting of a tamoxifen-inducible form of Cre recombinase (Cre-ERTM) that can be used for…
Investigators:
Andrew McMahon
Paul Danielian
David Rowitch
Case #: 2559