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3D-brain organoids: Enabling discovery through patient-derived brain organoids
The Arlotta team is developing a 3D brain organoid platform, which makes it possible to study aspects of human brain development and…
Investigators:
Paola Arlotta
Giorgia Quadrato
A drug discovery platform using novel labeled uridine analogs contribute to molecular biology research
This invention consists of novel 5-amino deoxyribouridine analogs. The analogs are labeled with a radioactive or fluorescent moiety and…
Investigators:
Gregory Verdine
Michael Storek
A novel and effective technology for target-based screening
Target-based screening allows for rapid identification of ligands for an increasing number of macromolecular targets and is commonly used in…
Investigators:
David Liu
Christoph Dumelin
David Gorin
Lynn McGregor
A system for the continuous directed evolution of biomolecules
Researchers in the laboratory of Professor David Liu have developed a platform that enables the continuous directed evolution of…
Investigators:
David Liu
Kevin Esvelt
Jacob Carlson
Ahmed Badran
A transgenic reporter system can be used for recombination-mediated modulation of gene activity in the developing mouse embryo
A transgenic reporter system consisting of a tamoxifen-inducible form of Cre recombinase (Cre-ERTM) that can be used for…
Investigators:
Andrew McMahon
Paul Danielian
David Rowitch
Absolute quantification of Proteins (AQUA)
This invention provides methods, reagents and kits for obtaining absolute quantification of proteins and their modifications directly from…
Investigators:
Steven Gygi
Scott Gerber
AlignAce motif searching software
Developed by genomics researchers at Harvard Medical School, AlignAce employs an algorithm that scans non-coding nucleic acid sequences at…
Investigators:
George Church
Jason Hughes
Frederick Roth
Analyzing trace gases at part-per-billion levels by rapid gas-phase cooling
This invention realizes a new idea of using buffer gas to rapidly cool small gas molecules to very low temperatures.
Investigators:
John Doyle
David Patterson
Animal model of diabetes and obesity
Mice with the JNK 1 and JNK2 genes knocked out were crossed with the obese mouse line (ob/ob) to create a mouse model of diabetes and…
Investigators:
Gokhan Hotamisligil
Michael Karin
Anti-PLK-1 monoclonal antibody
The monoclonal antibody PLK-1 recognizes the Macrophage Receptor with Collagenous structure (MARCO). The scavenger receptors (SRs) expressed…
Investigators:
Lester Kobzik
Aiyappa Palecanda