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Displaying: 1-10 of 18 Results
3D-brain organoids: Enabling discovery through patient-derived brain organoids
The Arlotta team is developing a 3D brain organoid platform, which makes it possible to study aspects of human brain development and…
Investigators:
Paola Arlotta
Giorgia Quadrato
Case #: 5942A drug discovery platform using novel labeled uridine analogs contribute to molecular biology research
This invention consists of novel 5-amino deoxyribouridine analogs. The analogs are labeled with a radioactive or fluorescent moiety and…
Investigators:
Gregory Verdine
Michael Storek
Case #: 1823A rapid and inducible method for repressing gene function
The Struhl lab has developed a rapid and effective means to inactivate a target gene, including genes involved in essential pathways. This…
Investigators:
Kevin Struhl
Zarmik Moqtaderi
Case #: 1426A transgenic reporter system can be used for recombination-mediated modulation of gene activity in the developing mouse embryo
A transgenic reporter system consisting of a tamoxifen-inducible form of Cre recombinase (Cre-ERTM) that can be used for…
Investigators:
Andrew McMahon
Paul Danielian
David Rowitch
Case #: 2559DeCoN: an interactive online database to enable multidimensional data mining of genome-wide in vivo transcriptional dynamics in the neocortex
DeCoN: The Developing Cortical Neuron Transcriptome Resource is a high throughput experimental resource, encompassing massively parallel RNA…
Investigators:
Paola Arlotta
Ryoji Amamoto
Emanuela Zuccaro
Case #: 6307Digital DNA Storage System
A startup emerging from George Church's lab intends to leverage new enzymatic approaches to develop a cost-effective digital DNA storage…
Investigators:
George Church
Case #:Directed evolution of proteins and nucleic acids using nonhomologous random recombination
The nonhomologous random recombination (NRR) method allows portions of nucleic acids to be recombined at sites where there is little or no…
Investigators:
David Liu
Joshua Bittker
Case #: 1885Electrophilic activity-based RNA probes reveal a self-alkylating RNA for RNA labeling
Probes that form covalent bonds with RNA molecules on the basis of their chemical reactivity would advance our ability to study the…
Investigators:
David Liu
Richard MacDonald
Case #: 5548Enhanced fidelity of sub-nanogram amplification
The importance of nucleic acid amplification from trace amounts of biological sample has increased with the expansion of genomic sequencing…
Investigators:
George Church
Kun Zhang
Case #: 2307Functional analysis of genes associated with psychiatric disorders
The molecular pathways that contribute to psychiatric disorders remain largely unknown. While numerous studies have highlighted possible…
Investigators:
Alexander Schier
Case #: 3673