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Altered specificity proteases that cleave and inactivate IL-23
SummaryIL-23 (interleukin 23) is a cytokine that is known to play a major role in the immune system and the development of…
Investigators:
David Liu
Case #: 6670Evolution of Sequence-Defined Highly Functionalized Nucleic Acid Polymers
DESCRIPTION Template-directed synthesis of modified DNA sequences can provide a rich source of material for generating new therapies…
Investigators:
David Liu
Case #: 6849Harnessing regulatory T cells to heal muscle injury and disease
A unique population of CD4+ FOXP3+ regulatory T cells (Tregs) was identified by Harvard investigators and shown to rapidly accumulate within…
Investigators:
Amy Wagers
Christophe Benoist
Diane Mathis
Case #: 4069In vivo gene editing in dystrophic muscle
Duchenne Muscular Dystrophy (DMD) is a debilitating disease caused by the absence of dystrophin, a protein expressed in muscle fibers. …
Investigators:
Amy Wagers
Case #: HU5305Mechanically-induced regeneration
Skeletal muscle and satellite cells are sensitive to biophysical and microenvironmental cues, and there is evidence that physical…
Investigators:
David Mooney
Case #: 6021Modulating gene activity on chondrocytes
Transgenic mice were generated in which the regulatory sequences for the Col2a1 gene were used to drive expression of Cre recombinase in…
Investigators:
Andrew McMahon
Fanxin Long
Case #: 2144Regenerative Cell Therapy for Skeletal Muscle Disorders
A startup emerging from Lee Rubin's lab aims to provide a long-term cell therapy regenerative solution for conditions that result in…
Investigators:
Lee Rubin
Case #: