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Harnessing regulatory T cells to heal muscle injury and disease
A unique population of CD4+ FOXP3+ regulatory T cells (Tregs) was identified by Harvard investigators and shown to rapidly accumulate within…
Investigators:
Amy Wagers
Christophe Benoist
Diane Mathis
Case #: 4069Identification of Key Pathogenic Factor of Cancer Cachexia
Cancer cachexia is a wasting syndrome that involves the progressive loss of skeletal muscle and adipose tissue. This devastating syndrome…
Investigators:
Norbert Perrimone
Case #: 7107In vivo gene editing in dystrophic muscle
Duchenne Muscular Dystrophy (DMD) is a debilitating disease caused by the absence of dystrophin, a protein expressed in muscle fibers. …
Investigators:
Amy Wagers
Case #: HU5305Modulating gene activity on chondrocytes
Transgenic mice were generated in which the regulatory sequences for the Col2a1 gene were used to drive expression of Cre recombinase in…
Investigators:
Andrew McMahon
Fanxin Long
Case #: 2144Proprietary non-opioid compounds to treat post-surgery pain without numbness or paralysis effects
Opioid painkillers commonly used to manage post-surgical pain are addictive, abuse-prone and cause frequent adverse events that worsen…
Investigators:
Clifford Woolf
Bruce Bean
Case #: HU5805