Yelena Bisharyan

Director of Business Development

Displaying: 1 - 10 of 29 Results

Red Blood Cell-Hitchhiking for Targeted Drug Delivery

Drug delivery utilizing nanocarriers (NCs) as a targeted approach has been actively pursued; however, even with the use of different affinity moieties such as antibodies to improve targeting and reduce off-target toxicity, NCs are predominately…

Investigators

  • Samir Mitragotri

DNA Destruction Through Novel and Adaptable Enzymes

Bacteria in mixed populations compete for resources and have several strategies on surviving and dominating other bacterial species. One method employs the injection of lethal effectors into adjacent cells. These effectors can disrupt cell membranes…

Investigators

  • Karine Gibbs

Inhibiting Microbial Metabolism of Levodopa to Increase Availability in the CNS

Parkinson’s disease (PD) impacts 10 million people globally, with 60,000 Americans newly diagnosed every year. Levodopa remains the gold standard treatment for PD, despite limitations including side effects and peripheral metabolism. Current…

Investigators

  • Emily Balskus

Reproducible Individual Brain Organoids

The human brain is a highly complex organ comprised of a variety of cell types and that are largely generated during embryonic development. While this process is invariable in vivo, it is unclear if this can be recapitulated outside of the embryo.…

Investigators

  • Paola Arlotta

Red blood cell-hitchhiking to boost delivery of antivirals and immunotherapies to the lungs

Researchers in Samir Mitragotri’s lab have developed a way to traffic therapeutics directly to the lungs following routine intravenous injection and hope to apply the technology to treatment of acute respiratory distress syndrome (ARDS) and…

Investigators

  • Samir Mitragotri

Oral delivery of vaccines

Researchers in Samir Mitragotri’s lab have developed a platform technology that can deliver vaccines through oral administration. The technology features ionic liquids, salts that exist in the liquid phase at room temperature, that preserve protein…

Investigators

  • Samir Mitragotri

Ionic liquid aerosols for respiratory complications related to COVID-19

Researchers in the lab of Samir Mitragotri have developed ionic liquid aerosols that have the potential to combat pulmonary bacterial infections. The technology may help to treat the respiratory conditions resulting from COVID-19 infection and…

Investigators

  • Samir Mitragotri

Repurposing of therapeutics to block SARS-CoV-2 protease activity and pathogenesis

Researchers in Christina Woo’s lab are studying the essential mechanisms by which SARS-CoV-2 (novel coronavirus) co-opts normal cellular processes for viral replication. One mechanism that the team has identified indicates that the virus encodes…

Investigators

  • Christina Woo

Utilizing the herpes simplex virus-based vaccine vectors to develop a COVID-19 vaccine

Researchers in the lab of David Knipe have constructed the HSV-1 based vaccine vector HSV-1 d106S. The vector can express viral, bacterial, or cancer gene products has been used to induce protective immunity in humanized mice against HIV and rhesus…

Investigators

  • David M. Knipe

Mutated IdsD proteins for treatment of Proteus mirabilis infections

Proteus mirabilis is part of the normal flora of the human gastrointestinal tract. It can also be found free living in water and soil. When this organism, however, enters the urinary tract, wounds, or the lungs it can become pathogenic. It commonly…

Investigators

  • Karine Gibbs

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