Yelena Bisharyan

Director of Business Development

Displaying: 1 - 10 of 10 Results

Preventing Stress-Induced Greying of Hair

Loss of hair pigmentation has long been associated with stress; however, stress-related changes at the level of the somatic cell have only recently been elucidated. The hair follicle consists of two stem cell populations: epithelial-derived hair…

Investigators

  • Ya-Chieh Hsu
  • Bing Zhang

Inhibiting Microbial Metabolism of Levodopa to Increase Availability in the CNS

Parkinson’s disease (PD) impacts 10 million people globally, with 60,000 Americans newly diagnosed every year. Levodopa remains the gold standard treatment for PD, despite limitations including side effects and peripheral metabolism. Current…

Investigators

  • Emily Balskus

Reproducible Individual Brain Organoids

The human brain is a highly complex organ comprised of a variety of cell types and that are largely generated during embryonic development. While this process is invariable in vivo, it is unclear if this can be recapitulated outside of the embryo.…

Investigators

  • Paola Arlotta

3D-brain organoids: Enabling discovery through patient-derived brain organoids

The Arlotta team is developing a 3D brain organoid platform, which makes it possible to study aspects of human brain development and neurodevelopmental disorders in a format amenable to large-scale production and genetic engineering.These organoids…

Investigators

  • Paola Arlotta
  • Giorgia Quadrato

FlicR: A bright and fast red fluorescent protein voltage indicator that reports neuronal activity

Fluorescent-protein-based voltage indicators enable imaging of the electrical activity of many genetically targeted neurons with high spatial and temporal resolution. FlicR is a new bright red fluorescent protein-based voltage indicator that has…

Investigators

  • Adam Ezra Cohen

Photostick: Physical isolation of single cells from tissue, for further propagation and single cell sequencing and omics

Photostick enables the physical selection of single cells from large populations in diverse environments. The novel process entails photochemical immobilization of live cells with patterned illumination, followed by removal of unwanted cells with…

Investigators

  • Adam Ezra Cohen
  • Miao-Ping Chien

Early-life nutrition additives to protect against inflammatory bowel disease

The Kasper lab has identified membrane glycosphingolipids from the commensal bacterium Bacteroides fragilis that reduce colonic invariant natural killer T (iNKT) cells – important contributors of inflammatory bowel disease pathogenesis. Exposure to…

Investigators

  • Dennis Kasper

Transgenic mice with fluorescently tagged neuronal mitochondria as a new tool to study axonal transport

Homozygous transgenic mouse stain B6.Cg-Tg(Thy1-CFP/COX8A)S2Lich/J (also know as Thy-CFP-MitoS) was developed by Dr. Jeffrey W. Lichtman at Harvard University. The mice express mitochondria-targeting Cyan Fluorescent Protein (CFP) in neuronal cell…

Investigators

  • Jeffrey W. Lichtman
  • Florence M. Bareyre
  • Thomas Misgeld
  • Martin Kerschensteiner

Corticospinal tract (CST)-YFP transgenic mice for monitoring axonal responses to spinal cord injury

Hemizygous transgenic mouse strain B6.Cg-Tg(Thy1-EYFP)15Jrs/J (also known as Thy-STOP-YFP) was developed by Dr. Joshua R. Sanes at Harvard University. The mouse strain harbors an Enhanced Yellow Fluorescent Protein (EYFP) controlled by mouse thymus…

Investigators

  • Joshua R. Sanes
  • Joshua R. Sanes
  • Florence M. Bareyre

Trioxacarcins and analogs: DNA-modifying compounds with potent anti-proliferative effects

The trioxacarcins are a new class of DNA-modifying natural products with potent antiproliferative effects (with subnanmolar IC70 values against lung, mammary, and CNS cancer cell lines). Trioxacarcin A, B, and C were first discovered and isolated…

Investigators

  • Andrew G. Myers
  • Jakub Svenda
  • Nicholas Hill
  • Robert Yu
  • Daniel J. Smaltz
  • Thomas Magauer

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