Yelena Bisharyan

Director of Business Development

Displaying: 1 - 10 of 14 Results

Preventing Stress-Induced Greying of Hair

Loss of hair pigmentation has long been associated with stress; however, stress-related changes at the level of the somatic cell have only recently been elucidated. The hair follicle consists of two stem cell populations: epithelial-derived hair…

Investigators

  • Ya-Chieh Hsu
  • Bing Zhang

Inhibiting Microbial Metabolism of Levodopa to Increase Availability in the CNS

Parkinson’s disease (PD) impacts 10 million people globally, with 60,000 Americans newly diagnosed every year. Levodopa remains the gold standard treatment for PD, despite limitations including side effects and peripheral metabolism. Current…

Investigators

  • Emily Balskus

Reproducible Individual Brain Organoids

The human brain is a highly complex organ comprised of a variety of cell types and that are largely generated during embryonic development. While this process is invariable in vivo, it is unclear if this can be recapitulated outside of the embryo.…

Investigators

  • Paola Arlotta

Utilizing the herpes simplex virus-based vaccine vectors to develop a COVID-19 vaccine

Researchers in the lab of David Knipe have constructed the HSV-1 based vaccine vector HSV-1 d106S. The vector can express viral, bacterial, or cancer gene products and has been used to induce protective immunity in humanized mice against HIV and…

Investigators

  • David M. Knipe

3D-brain organoids: Enabling discovery through patient-derived brain organoids

The Arlotta team is developing a 3D brain organoid platform, which makes it possible to study aspects of human brain development and neurodevelopmental disorders in a format amenable to large-scale production and genetic engineering.These organoids…

Investigators

  • Paola Arlotta
  • Giorgia Quadrato

FlicR: A bright and fast red fluorescent protein voltage indicator that reports neuronal activity

Fluorescent-protein-based voltage indicators enable imaging of the electrical activity of many genetically targeted neurons with high spatial and temporal resolution. FlicR is a new bright red fluorescent protein-based voltage indicator that has…

Investigators

  • Adam Ezra Cohen

Small molecule inhibitors of Zika, dengue and other flaviviruses

Currently, broadly-protective antivirals targeting flaviviruses such as Zika, Dengue and West Nile viruses, are not available. Researchers in the laboratory of Dr. Priscilla Yang have identified a group of small molecules, including a prototype…

Investigators

  • Priscilla Yang

Photostick: Physical isolation of single cells from tissue, for further propagation and single cell sequencing and omics

Photostick enables the physical selection of single cells from large populations in diverse environments. The novel process entails photochemical immobilization of live cells with patterned illumination, followed by removal of unwanted cells with…

Investigators

  • Adam Ezra Cohen
  • Miao-Ping Chien

Enhancers of Gene Therapy

Currently available gene therapy technologies rely on either plasmid DNA or viral vector transduction to enable gene transfer. However, such methods often suffer from poor direct expression and insufficient incorporation of foreign genetic material.…

Investigators

  • David M. Knipe
  • Megan Horn Orzalli

Early-life nutrition additives to protect against inflammatory bowel disease

The Kasper lab has identified membrane glycosphingolipids from the commensal bacterium Bacteroides fragilis that reduce colonic invariant natural killer T (iNKT) cells – important contributors of inflammatory bowel disease pathogenesis. Exposure to…

Investigators

  • Dennis Kasper

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