DBD Search
Yelena Bisharyan
Director of Business Development
Displaying: 1 - 10 of 31 Results
Invention
Organ-on-a-Chip Determines if Injected Medicines Work
Around 16 billion injections are performed worldwide each year, mostly for therapeutic applications including the delivery of biologics such as insulin and monoclonal antibodies. Compared to intravenous injections, subcutaneous injections are…
Investigators
- Samir Mitragotri
Invention
Regeneration of Skin Tissue
The amazing regenerative capability of fetal skin has been known for decades. While postnatal skin heals through fibrosis (scar formation) and only the epidermis can be restored, fetal skin has enormous regenerative capability and heals without scar…
Investigators
- Ya-Chieh Hsu
Invention
Waging a War on Hyperpigmentation
Pigmentation is highly heritable, as genetic factors modulate the amount and distribution of melanin to the skin, hair, and eyes. However, endocrine factors associated with stress, pregnancy, and aging often induce temporary or permanent changes in…
Investigators
- Ya-Chieh Hsu
Invention
More Hair Here, Less Hair There
Although hair loss is common, it is often considered an undesirable outcome. Another popular opinion is that body hair can be just as unpleasant. Hair growth undergoes a cycle of rest and growth, where hair follicle stem cells (HFSCs) either remain…
Investigators
- Ya-Chieh Hsu
Invention
Targeting Mechanisms of Stress-Related Hair Loss
More than 80 percent of men and nearly half of women experience significant hair loss during their lifetime. For many, the thinning begins well before middle age. Everyone has a story to share about the annoying effects of hair loss, which range…
Investigators
- Ya-Chieh Hsu
Invention
Preventing Stress-Induced Greying of Hair
Loss of hair pigmentation has long been associated with stress; however, stress-related changes at the level of the somatic cell have only recently been elucidated. The hair follicle consists of two stem cell populations: epithelial-derived hair…
Investigators
- Ya-Chieh Hsu
- Bing Zhang
Invention
Inhibiting Microbial Metabolism of Levodopa to Increase Availability in the CNS
Parkinson’s disease (PD) impacts 10 million people globally, with 60,000 Americans newly diagnosed every year. Levodopa remains the gold standard treatment for PD, despite limitations including side effects and peripheral metabolism. Current…
Investigators
- Emily Balskus
Invention
Reproducible Individual Brain Organoids
The human brain is a highly complex organ comprised of a variety of cell types and that are largely generated during embryonic development. While this process is invariable in vivo, it is unclear if this can be recapitulated outside of the embryo.…
Investigators
- Paola Arlotta
Invention
3D-brain organoids: Enabling discovery through patient-derived brain organoids
The Arlotta team is developing a 3D brain organoid platform, which makes it possible to study aspects of human brain development and neurodevelopmental disorders in a format amenable to large-scale production and genetic engineering.These organoids…
Investigators
- Paola Arlotta
- Giorgia Quadrato
Invention
FlicR: A bright and fast red fluorescent protein voltage indicator that reports neuronal activity
Fluorescent-protein-based voltage indicators enable imaging of the electrical activity of many genetically targeted neurons with high spatial and temporal resolution. FlicR is a new bright red fluorescent protein-based voltage indicator that has…
Investigators
- Adam Ezra Cohen