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Small Molecule Therapeutics
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Displaying: 11 - 18 of 18 Results
In vitro models and method of treatment for amyotrophic lateral sclerosis (ALS)
It has been impossible to isolate viable human motor neurons from patients or from postmortem samples to investigate the mechanisms leading to neural degeneration in ALS. A potential solution is to use embryonic stem cells (ESC) as a renewable…
DBD
- Vivian Berlin
Investigators
- Kevin Eggan
- Francesco Di Giorgio
Potent OGT inhibitors for the treatment of cancer and diabetic complications
First-in-class and potent OGT inhibitors The Walker group has developed novel high throughput assays (HTS) and screened 200,000 compounds at the Institute for Chemistry and Cell Biology (ICCB) at Harvard Medical School, and identified several…
DBD
- Vivian Berlin
Investigators
- Suzanne Walker Kahne
- Michael Lazarus
- Benjamin Gross
Trioxacarcins and analogs: DNA-modifying compounds with potent anti-proliferative effects
The trioxacarcins are a new class of DNA-modifying natural products with potent antiproliferative effects (with subnanmolar IC70 values against lung, mammary, and CNS cancer cell lines). Trioxacarcin A, B, and C were first discovered and isolated…
DBD
- Yelena Bisharyan
Investigators
- Andrew Myers
- Jakub Svenda
- Nicholas Hill
- Robert Yu
- Daniel Smaltz
- Thomas Magauer
Small molecule inhibitors of Ebola virus entry
Background: Human cells that are susceptible to infection by pathogenic viruses express surface membrane proteins that mediate attachment and membrane fusion activity of virus glycoproteins. There are strong structural and functional similarities…
DBD
- Irit Ben-Chelouche
Investigators
- Dennis Kasper
- Kyungae Lee
- Tao Ren
- James Cunningham
- Kartik Chandran
Small-molecule macrocycles: Potent and selective Src kinase inhibitors
Macrocyclic compounds have unique properties that allow them to cover regions of chemical space not addressed by other small-molecule structural classes. By performing an in vitro selection screen of a broad untargeted DNA-encoded library of 13,824…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
- Ralph Kleiner
Targeted inhibition of the SREBP-mediator interaction as a novel therapeutic
While most therapeutic approaches aimed at altering gene expression programs target upstream signaling pathways or nuclear translocation checkpoints, Scientists at the Wagner lab have provided mechanistic insights supporting an alternative approach,…
DBD
- Grant Zimmermann
Investigators
- Gerhard Wagner
- Anders Naar
- Haribabu Arthanari
Inhibiting Microbial Metabolism of Levodopa to Increase Availability in the CNS
Parkinson’s disease (PD) impacts 10 million people globally, with 60,000 Americans newly diagnosed every year. Levodopa remains the gold standard treatment for PD, despite limitations including side effects and peripheral metabolism. Current…
DBD
- Yelena Bisharyan
Investigators
- Emily Balskus
Preventing Stress-Induced Greying of Hair
Loss of hair pigmentation has long been associated with stress; however, stress-related changes at the level of the somatic cell have only recently been elucidated. The hair follicle consists of two stem cell populations: epithelial-derived hair…
DBD
- Yelena Bisharyan
Investigators
- Ya-Chieh Hsu
- Bing Zhang