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Phaeobacticides - Potent and selective new class of algae growth inhibitors
Algae are a diverse group of uni- and multicellular plants that grow in water. Undesired and uncontrolled algal blooms are a recurring problem in bodies of water such as swimming pools, aquaculture ponds, aquariums, industrial drainage systems and…
DBD
- Grant Zimmermann
Investigators
- Jon Clardy
- Roberto Kolter
- Mohammad Seyedsayamdost
- Rebecca Case
Small-molecule macrocycles: Potent and selective Src kinase inhibitors
Macrocyclic compounds have unique properties that allow them to cover regions of chemical space not addressed by other small-molecule structural classes. By performing an in vitro selection screen of a broad untargeted DNA-encoded library of 13,824…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
- Ralph Kleiner
Monolithically-integrated graphene structures as sensors
Graphene is a single, atomic-layer thick two-dimensional sheet of bonded carbon atoms that is characterized by superb electric and mechanical properties, thermal conductivity, and optical transparency. Graphene is a promising candidate material for…
DBD
- Christopher Petty
Investigators
- Charles Lieber
- Jang-Ung Park
- SungWoo Nam
Bisphosphonates as novel adjuvants to enhance the adaptive immune response, validated with common types of vaccine antigens and commercial vaccines
Despite decades of adjuvant research, only a handful of adjuvants have been approved in seven major global markets and only two (Alum and GSK’s AS04) are licensed in the US. The availability of additional adjuvants has been minimized due to…
DBD
- Irit Ben-Chelouche
Investigators
- Ulrich von Andrian
- Matteo Iannacone
- Elena Tonti
- Elliott Moseman
Controllable motion damping for prosthetic limbs and robotics
The technology offered here provides instant damping control and tunable shock absorption in low-power mechanical systems. The invention is a soft structure which contains magneto-rheological fluid (MRF), which hardens under applied magnetic fields.…
DBD
- Sam Liss
Investigators
- Robert Wood
- Carmel Majidi
Novel lipid hormone for identifying and treating metabolic disease
Scientists in the Harvard School of Public Health have identified fatty acid C16:1n7-palmitoleate, a novel signaling lipid produced by adipose tissue, that protects mice from the detrimental effects of long-term consumption of high-fat diets. They…
DBD
- Vivian Berlin
Investigators
- Gokhan Hotamisligil
- Dariush Mozaffarian
- Haiming Cao
DBD
- Sam Liss
Investigators
- Marko Loncar
- Qimin Quan
A new approach to NMR: High resolution spatial holographic encoding using traveling wave MR
This technology is for using a high field MR system to record interference patterns within biological phantoms combined with new spatial encoding methods to give contrast at resolution limits far exceeding traditional gradient-based encoding…
DBD
- Sam Liss
Investigators
- Andrew Kiruluta
Fzd2 - novel anti-cancer therapeutic target
The role of β-catenin accumulation in the development of tumorigenicity has been well documented to date, with various mutations in β-catenin, APC, and axin genes typically to blame. Although β-catenin accumulation plays a role in hepatocellular…
DBD
- Irit Ben-Chelouche
Investigators
- Gavin MacBeath
- Taran Gujral
Filtration system for small- to medium-scale wastewater and water treatment
This invention is a filtration technology for water purification, based on an electrochemically active carbon nanotube filter, intended initially for wastewater treatment and water purification. This approach combines the advantages of filtration…
DBD
- Sam Liss
Investigators
- Chad Vecitis
- Kirsten Van Fossen