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Quantum Network-Based Voting: Enhancing Election Integrity and Efficiency
Voting security is crucial for preventing fraud, maintaining public trust, and is a cornerstone of democratic governance. The development of large-scale quantum computers opens the possibility of efficiently solving advanced voting protocols and…
DBD
- Sam Liss
Investigators
- Mikhail Lukin
Unlocking Long-Range Entangled Quantum States
Long-range entangled quantum states are a key part of realizing the full potential of quantum computing technology; they provide the foundation for error correction, enable universal quantum computation, and enhance quantum algorithms and metrology,…
DBD
- Sam Liss
Investigators
- Ashvin Vishwanath
Control of host homeostatic immunity by a microbiome-derived immunomodulatory lipid
Akkermansia muciniphila, a species of the human gut microbiome, has been robustly associated with positive systemic effects on host metabolism and obesity, favorable response to checkpoint blockade in cancer immunotherapy, and maintenance of…
DBD
- Grant Zimmermann
Investigators
- Jon Clardy
RGMb-deficient T cells for overcoming resistance to immune checkpoint blockade
Immune checkpoint blockade therapies targeting PD-1 or PD-L1 have been approved for more than 25 different tumors. However, many patients do not respond to PD-1/PD-L1 checkpoint blockade. The Sharpe lab at Harvard Medical School has identified that…
DBD
- Grant Zimmermann
Investigators
- Arlene Sharpe
- Dennis Kasper
PD-L2 modulated dendritic cells for cancer immunotherapy
Immune checkpoint blockade therapies targeting PD-1 or PD-L1 have been approved for more than 25 different tumors. However, many patients do not respond to PD-1/PD-L1 checkpoint blockade. The Sharpe lab has identified that dendritic cells (DCs) with…
DBD
- Grant Zimmermann
Investigators
- Arlene Sharpe
- Dennis Kasper
Inhibition of STAG1 using ASOs for treatment of STAG2-deficient cancers
The cohesin complex is one of the most frequently mutated protein complexes in cancer. Cohesin mutations are associated with poor survival and there are no therapies that selectively target cohesin-mutant cancers. STAG2 is the most frequently…
DBD
- Irit Ben-Chelouche
Investigators
- Karen Adelman
Breast and soft tissue reconstructive surgery
Breast reconstruction and augmentation options are limited and come with significant health risks. Artificial silicone or saline implants must be replaced within 10 to 15 years. Breast reconstruction using autologous tissue flaps, taking tissue from…
DBD
- Christopher Petty
Investigators
- Luba Perry
- Jennifer Lewis
Regeneration of Skin Tissue
The amazing regenerative capability of fetal skin has been known for decades. While postnatal skin heals through fibrosis (scar formation) and only the epidermis can be restored, fetal skin has enormous regenerative capability and heals without scar…
DBD
- Yelena Bisharyan
Investigators
- Ya-Chieh Hsu
Waging a War on Hyperpigmentation
Pigmentation is highly heritable, as genetic factors modulate the amount and distribution of melanin to the skin, hair, and eyes. However, endocrine factors associated with stress, pregnancy, and aging often induce temporary or permanent changes in…
DBD
- Yelena Bisharyan
Investigators
- Ya-Chieh Hsu
More Hair Here, Less Hair There
Although hair loss is common, it is often considered an undesirable outcome. Another popular opinion is that body hair can be just as unpleasant. Hair growth undergoes a cycle of rest and growth, where hair follicle stem cells (HFSCs) either remain…
DBD
- Yelena Bisharyan
Investigators
- Ya-Chieh Hsu