Orai1 Knock Out Mice

The targeted Orai1 gene encodes a pore subunit of the store-operated calcium channel, CRAC (calcium release-activated calcium) channel. Mutations in this gene have been associated with primary immunodeficiency-9 and tubular aggregate myopathy-2. These knock-out mice carry an allele of Orai1 in which exon 1 has been excised. No gene product (mRNA) is detected by RT-PCR analysis of CD4+ T cells and CD19+ B cells from homozygotes. Fewer than expected homozygotes on the C57BL/6 background are born, and homozygotes are perinatal lethal, with all homozygous pups dying by 1.5 days after birth. MEFs isolated from homozygotes exhibit significantly impaired store-operated Ca2+ influx.

Jax Stock Number: 23352

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