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Cell Interrogation/Tissue Engineering
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Displaying: 1 - 7 of 7 Results
Polymeric material for dentin restoration
David Mooney’s lab has demonstrated the use of triacrylates TMPTA and PETA as tools for the repair of dental tissues. They found that dental pulp stem cells (DPSCs) adhered to these triacrylate polymers, which had been cured by visible light, and…
Investigators
- David Mooney
3D-brain organoids: Enabling discovery through patient-derived brain organoids
The Arlotta team is developing a 3D brain organoid platform, which makes it possible to study aspects of human brain development and neurodevelopmental disorders in a format amenable to large-scale production and genetic engineering.These organoids…
DBD
- Yelena Bisharyan
Investigators
- Paola Arlotta
- Giorgia Quadrato
Photostick: Physical isolation of single cells from tissue, for further propagation and single cell sequencing and omics
Photostick enables the physical selection of single cells from large populations in diverse environments. The novel process entails photochemical immobilization of live cells with patterned illumination, followed by removal of unwanted cells with…
DBD
- Yelena Bisharyan
Investigators
- Adam Cohen
- Miao-Ping Chien
A system for in vivo generation of protective CD8+ T lymphocytes and other cells of hematopoietic origin
Differentiated CD8+ effector T cells mediate long-term immunity and protection against infectious diseases and cancer. Naive T cells are refractory to transduction with viral vectors without extensive ex vivo manipulations. A team of researchers at…
DBD
- Irit Ben-Chelouche
Investigators
- Arlene Sharpe
- Nicholas Haining
Cyborg organoids with fully integrated nanoelectronics
Researchers from the Liu lab at Harvard have grown organoids with fully integrated sensors that grow with the developing cells, giving them the unique ability to study the early stages of organ development. Organoids are 3D clusters of cells that…
DBD
- Christopher Petty
Investigators
- Jia Liu
- Kewang Nan
- Qiang Li
Reproducible Individual Brain Organoids
The human brain is a highly complex organ comprised of a variety of cell types and that are largely generated during embryonic development. While this process is invariable in vivo, it is unclear if this can be recapitulated outside of the embryo.…
DBD
- Yelena Bisharyan
Investigators
- Paola Arlotta
Breast and soft tissue reconstructive surgery
Breast reconstruction and augmentation options are limited and come with significant health risks. Artificial silicone or saline implants must be replaced within 10 to 15 years. Breast reconstruction using autologous tissue flaps, taking tissue from…
DBD
- Christopher Petty
Investigators
- Luba Perry
- Jennifer Lewis