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Displaying: 1 - 10 of 13 Results
Digital DNA Storage System
A startup emerging from George Church's lab intends to leverage new enzymatic approaches to develop a cost-effective digital DNA storage system. (Image credit: Shutterstock/Chornyi Serhii.)The volume of global digital information is growing…
DBD
- Grant Zimmermann
Investigators
- George Church
SIM-PAL: proteome wide identification of small molecule binding sites
Precise target identification for small molecules is an important and essential step in drug development. Despite its importance, there are very few unbiased, proteome-wide approaches aimed at identifying binding partners for small molecules. In…
DBD
- Grant Zimmermann
Investigators
- Christina Woo
Polycystic Kidney Disease: Mechanistic Dissection and Discovering Precision Therapeutic Targets
Autosomal-dominant polycystic kidney disease (ADPKD) is a life-threatening monogenic disease that affects nearly 1 million people in the U.S. alone. ADPKD represents a very large unmet medical need, currently without remedy. It is characterized by…
DBD
- Grant Zimmermann
Investigators
- Adrian Salic
3D-brain organoids: Enabling discovery through patient-derived brain organoids
The Arlotta team is developing a 3D brain organoid platform, which makes it possible to study aspects of human brain development and neurodevelopmental disorders in a format amenable to large-scale production and genetic engineering.These organoids…
DBD
- Yelena Bisharyan
Investigators
- Paola Arlotta
- Giorgia Quadrato
Photostick: Physical isolation of single cells from tissue, for further propagation and single cell sequencing and omics
Photostick enables the physical selection of single cells from large populations in diverse environments. The novel process entails photochemical immobilization of live cells with patterned illumination, followed by removal of unwanted cells with…
DBD
- Yelena Bisharyan
Investigators
- Adam Cohen
- Miao-Ping Chien
Immunology and Computational Biology Partnership
Professors Diane Mathis and Christophe Benoist at Harvard Medical School, together with other world-renowned immunologists and computational biologists from multiple research institutions, have created the Immunological Genome Project – Immgen…
DBD
- Irit Ben-Chelouche
Investigators
- Diane Mathis
- Christophe Benoist
A drug discovery platform using novel labeled uridine analogs contribute to molecular biology research
This invention consists of novel 5-amino deoxyribouridine analogs. The analogs are labeled with a radioactive or fluorescent moiety and incorporated into nucleic acid by PCR for use in genomic research applications. One assay design involves a…
DBD
- Vivian Berlin
Investigators
- Gregory Verdine
- Michael Storek
Directed evolution of proteins and nucleic acids using nonhomologous random recombination
The nonhomologous random recombination (NRR) method allows portions of nucleic acids to be recombined at sites where there is little or no sequence homology. This increases the frequency at which novel sequences are generated, allowing a more…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
- Joshua Bittker
Enhanced fidelity of sub-nanogram amplification
The importance of nucleic acid amplification from trace amounts of biological sample has increased with the expansion of genomic sequencing in various clinical and research-oriented applications. This invention characterizes techniques to reduce…
DBD
- Maryanne Fenerjian
Investigators
- George Church
- Kun Zhang
A transgenic reporter system can be used for recombination-mediated modulation of gene activity in the developing mouse embryo
A transgenic reporter system consisting of a tamoxifen-inducible form of Cre recombinase (Cre-ERTM) that can be used for recombination-mediated modulation of gene activity in the developing mouse embryo. Using the enhancer of the Wnt1 gene to…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
- Paul Danielian
- David Rowitch