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Regenerative Cell Therapy for Skeletal Muscle Disorders
A startup emerging from Lee Rubin's lab aims to provide a long-term cell therapy regenerative solution for conditions that result in reduced or improper skeletal muscle regeneration. (Image credit: B.D. Colen/Harvard Staff.)Cell therapies hold…
DBD
- Vivian Berlin
Investigators
- Lee Rubin
Mechanically-induced regeneration
Skeletal muscle and satellite cells are sensitive to biophysical and microenvironmental cues, and there is evidence that physical manipulation of damaged muscle may promote recovery. David Mooney’s lab has used biphasic ferrogel scaffolds to create…
Investigators
- David Mooney
Evolution of Sequence-Defined Highly Functionalized Nucleic Acid Polymers
DESCRIPTION Template-directed synthesis of modified DNA sequences can provide a rich source of material for generating new therapies featuring modified nucleic acid polymers. The Liu lab has previously developed pioneering methods to generate…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
Modulating gene activity on chondrocytes
Transgenic mice were generated in which the regulatory sequences for the Col2a1 gene were used to drive expression of Cre recombinase in chondrocytes. The strain initiates Cre-mediated recombination predominantly in immature chondrocytes and the…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
- Fanxin Long