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Displaying: 121 - 130 of 270 Results
Ultra fast method for chiral catalyst discovery
This invention is a novel method for determining--in less than 24 hours--enantiomeric ratios, percent conversions, and absolute configurations of all members of a chemical library containing at least 10,000 reaction products. Reaction mixtures are…
DBD
- Vivian Berlin
Investigators
- Matthew Shair
- Gregory Korbel
- Gojko Lilac
Method for producing site-specific recombination of DNA in a transgenic non-human mammal at chromosomal regions containing Flp-recognition sites
A method is disclosed for producing site-specific recombination of DNA in a transgenic non-human mammal at chromosomal regions containing Flp-recognition sites (e.g., a DNA sequence containing an FRT site). The invention in particular discloses the…
DBD
- Grant Zimmermann
Investigators
- Susan Dymecki
- A. Stewart
Time and concentration warping software for RNA and protein expression data
The predominant strategies for drug discovery today employ high-throughput screens and microarray-based methods that generate large data sets. Increasingly, these techniques are being used to study biological processes as a function of time and/or…
DBD
- Maryanne Fenerjian
Investigators
- George Church
- John Aach
A drug discovery platform using novel labeled uridine analogs contribute to molecular biology research
This invention consists of novel 5-amino deoxyribouridine analogs. The analogs are labeled with a radioactive or fluorescent moiety and incorporated into nucleic acid by PCR for use in genomic research applications. One assay design involves a…
DBD
- Vivian Berlin
Investigators
- Gregory Verdine
- Michael Storek
anti-MARCO monoclonal antibody
The monoclonal antibody recognizes the Macrophage Receptor with Collagenous structure (MARCO). The scavenger receptors (SRs) expressed by macrophages are thought to play an important role in the immune response against bacteria by mediating binding…
DBD
- Grant Zimmermann
Investigators
- Lester Kobzik
- Aiyappa Palecanda
Selective deposition of cells in microwells
This invention is a method of selectively functionalizing indentations (such as wells or channels in microfluidic systems) or protrusions on a substrate such that, for example, cells selectively bind to the indentations or the protrusions. The…
DBD
- Sam Liss
Investigators
- George Whitesides
- Emanuele Ostuni
- Christopher Chen
- Donald Ingber
Directed evolution of proteins and nucleic acids using nonhomologous random recombination
The nonhomologous random recombination (NRR) method allows portions of nucleic acids to be recombined at sites where there is little or no sequence homology. This increases the frequency at which novel sequences are generated, allowing a more…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
- Joshua Bittker
Absolute quantification of Proteins (AQUA)
This invention provides methods, reagents and kits for obtaining absolute quantification of proteins and their modifications directly from cell lysates. In particular, the invention provides peptide internal standards for use in high performance…
DBD
- Grant Zimmermann
Investigators
- Steven Gygi
- Scott Gerber
Microfluidic arrays for multiplex detection of analyts
This invention is a microfluidic array apparatus and a method of performing multiple analyses on multiple samples simultaneously, utilizing nanoliter volumes of reagents. It has two embodiments, the first consists of N microfluidic channels, perhaps…
DBD
- Christopher Petty
Investigators
- George Whitesides
- Rustem Ismagilov
- Jessamine Lee
- Paul Kenis
- Xingyu Jiang
- Rosaria Ferrigno
MicroArray spot LINEar regression (MASLINER) software
Signal intensities between samples on a microarrary typically vary by as much as three to four orders of magnitude, frustrating efforts at comparative analysis of samples assayed in parallel. At any given laser power or photomultiplier tube gain…
DBD
- Maryanne Fenerjian
Investigators
- George Church
- John Aach
- Aimee Dudley
- Martin Steffen