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Displaying: 181 - 190 of 266 Results
Improved performance of copper interconnects
Copper (Cu) is now the preferred material for interconnections in ICs because it conducts better and lasts longer than aluminum. However, there are well-known problems with copper interconnects. Copper tends to migrate out of the wiring, degrading…
DBD
- Christopher Petty
Investigators
- Roy Gordon
- Yeung Au
- Youbo Lin
- Harish Bhandari
Silicon-based photodiodes for enhanced infrared detection, quick response and low cost
The technology offered here is for the creation of an “impurity enhanced” silicon material with unique optelectric properties. The material is created by employing an ion-implantation technique using a nanosecond laser to melt the basis of single…
DBD
- Christopher Petty
Investigators
- Michael Aziz
- Daniel Recht
- Aurore Said
- Jeffery Warrender
Trioxacarcins and analogs: DNA-modifying compounds with potent anti-proliferative effects
The trioxacarcins are a new class of DNA-modifying natural products with potent antiproliferative effects (with subnanmolar IC70 values against lung, mammary, and CNS cancer cell lines). Trioxacarcin A, B, and C were first discovered and isolated…
DBD
- Yelena Bisharyan
Investigators
- Andrew Myers
- Jakub Svenda
- Nicholas Hill
- Robert Yu
- Daniel Smaltz
- Thomas Magauer
High-flux, low-power diamond nanowire single-photon source arrays: an enabling material for optical and quantum computing and cryptography
The novel approach taken by the Harvard researchers was to apply top-down nanofabrication techniques to define large arrays of vertically oriented nanowire antennas in a single-crystal diamond substrate. Briefly, structures were made from a…
DBD
- Sam Liss
Investigators
- Marko Loncar
- Thomas Babinec
- Birgit Yao
- Mughees Khan
- Yinan Zhang
- Philip Hemmer
Small molecule inhibitors of Ebola virus entry
Background: Human cells that are susceptible to infection by pathogenic viruses express surface membrane proteins that mediate attachment and membrane fusion activity of virus glycoproteins. There are strong structural and functional similarities…
DBD
- Irit Ben-Chelouche
Investigators
- Dennis Kasper
- Kyungae Lee
- Tao Ren
- James Cunningham
- Kartik Chandran
Analyzing trace gases at part-per-billion levels by rapid gas-phase cooling
This invention realizes a new idea of using buffer gas to rapidly cool small gas molecules to very low temperatures.
DBD
- Christopher Petty
Investigators
- John Doyle
- David Patterson
Materials presenting Notch signaling molecules to control cell behavior
This technology has direct application to stem cell therapy, regenerative medicine, and tissue engineering in vivo (in the patient) and in vitro (in tissue culture dish). -In vitro stem cell manipulation- Using this method of introducing Notch…
Investigators
- David Mooney
- Lan Cao
- Kamal Bouhadir
High-sensitivity, high-throughput biosensor capable of detecting biomarkers without external fluorescent labels
This invention describes a combination of technologies that produce a miniature optical biosensor array which is capable of detecting biomarkers without requiring external fluorescent labels. This label-free approach uses a sample placed in a…
DBD
- Sam Liss
Investigators
- Frank Vollmer
- Qimin Quan
- Marko Loncar
Phaeobacticides - Potent and selective new class of algae growth inhibitors
Algae are a diverse group of uni- and multicellular plants that grow in water. Undesired and uncontrolled algal blooms are a recurring problem in bodies of water such as swimming pools, aquaculture ponds, aquariums, industrial drainage systems and…
DBD
- Grant Zimmermann
Investigators
- Jon Clardy
- Roberto Kolter
- Mohammad Seyedsayamdost
- Rebecca Case
Small-molecule macrocycles: Potent and selective Src kinase inhibitors
Macrocyclic compounds have unique properties that allow them to cover regions of chemical space not addressed by other small-molecule structural classes. By performing an in vitro selection screen of a broad untargeted DNA-encoded library of 13,824…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
- Ralph Kleiner