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Inhibition of STAG1 using ASOs for treatment of STAG2-deficient cancers
The cohesin complex is one of the most frequently mutated protein complexes in cancer. Cohesin mutations are associated with poor survival and there are no therapies that selectively target cohesin-mutant cancers. STAG2 is the most frequently…
DBD
- Irit Ben-Chelouche
Investigators
- Karen Adelman
Breast and soft tissue reconstructive surgery
Breast reconstruction and augmentation options are limited and come with significant health risks. Artificial silicone or saline implants must be replaced within 10 to 15 years. Breast reconstruction using autologous tissue flaps, taking tissue from…
DBD
- Christopher Petty
Investigators
- Luba Perry
- Jennifer Lewis
Regeneration of Skin Tissue
The amazing regenerative capability of fetal skin has been known for decades. While postnatal skin heals through fibrosis (scar formation) and only the epidermis can be restored, fetal skin has enormous regenerative capability and heals without scar…
Investigators
- Ya-Chieh Hsu
Waging a War on Hyperpigmentation
Pigmentation is highly heritable, as genetic factors modulate the amount and distribution of melanin to the skin, hair, and eyes. However, endocrine factors associated with stress, pregnancy, and aging often induce temporary or permanent changes in…
Investigators
- Ya-Chieh Hsu
More Hair Here, Less Hair There
Although hair loss is common, it is often considered an undesirable outcome. Another popular opinion is that body hair can be just as unpleasant. Hair growth undergoes a cycle of rest and growth, where hair follicle stem cells (HFSCs) either remain…
Investigators
- Ya-Chieh Hsu
Targeting Mechanisms of Stress-Related Hair Loss
More than 80 percent of men and nearly half of women experience significant hair loss during their lifetime. For many, the thinning begins well before middle age. Everyone has a story to share about the annoying effects of hair loss, which range…
Investigators
- Ya-Chieh Hsu
Desodiated Sodium Transition Metal Oxides For Primary Batteries
Advancements in battery technology have been a research focus for many reasons, including cost reduction. Sodium-ion batteries have emerged as a promising alternative to lithium-ion batteries due to the abundance and low cost of sodium compounds.…
DBD
- Christopher Petty
Investigators
- Xin Li
Copolymers For Stabilizing Emulsions And/Or Forming Interfacial Films, And Methods Thereof
Emulsions typically consist of dispersed droplets in a continuous phase, and they naturally tend to separate due to interfacial energy, leading to droplet coalescence. Copolymers are designed for stabilizing emulsions or droplets, which are mixtures…
Investigators
- David Weitz
PFAS-free Textile Coatings
Fluorinated polymers, commonly referred to as PFAS, are used as surface coatings in a variety of common consumer products, such as cookware, food packaging, and textiles. These chemicals make products non-stick or water-repellant due to their…
DBD
- Christopher Petty
Investigators
- Joanna Aizenberg
Organ-on-a-Chip Determines if Injected Medicines Work
Around 16 billion injections are performed worldwide each year, mostly for therapeutic applications including the delivery of biologics such as insulin and monoclonal antibodies. Compared to intravenous injections, subcutaneous injections are…
Investigators
- Samir Mitragotri