B6.Cg-Shhtm1(EGFP/cre)Cjt/J mice developed in the laboratory of Dr. Clifford Tabin
This mouse stain, also known as Shhgfpcre was originally described in Cell in 2004. The mice express GFP in all cell expressing Shh, and specifically, in the distal posterior region of the limb buds of embryos aged embryonic day 10 to 12. Mice homozygous for the mutation have abnormalities in limb development and are not not viable or fertile. Heterozygous mutant mice are do not exhibit any physical or behavioral abnormalities.
The detailed description of this mouse stain can be found here.
The mice can be used to study skeletal defects and embryonic development, including development of the CNS and urinary system.
The mouse strain is available for licensing from Harvard University and will be provided by The Jackson Laboratory.