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Faster testing for illicit drugs

Researchers in the Whitesides lab have developed a portable and easy to use Magneto-Archimedes Levitation (MagLev) device for identifying the composition of illicit drug mixtures. A diamagnetic sample (in this case, an unknown drug mixture) is…

Investigators

  • George Whitesides
  • Christoffer Abrahamsson
  • Amit Nagarkar
  • Michael Fink
  • Daniel Preston
  • Markus Nemitz
  • Shencheng Ge
  • Joseph Bozenko

Isolating live cells after high-throughput, long-term, time-lapse microscopy

Researchers led by Johan Paulsson have engineered a high-throughput microfluidic device for multigenerational culturing, imaging, and tracking of single-cell lineages. The platform is highly customizable and is compatible with many cell types,…

Investigators

  • Johan Paulsson

Machine learning to accelerate diagnostics and therapeutics for COVID-19

The COVID-19 pandemic demands a rapid response of science, diagnostics, and therapeutics. Debora Marks’ lab at Harvard Medical School aims to accelerate those efforts using predictive models of the SARS-CoV2-19 sequences and 3D structures. The lab’s…

Investigators

  • Debora Marks

Microfluidic trapping chip for culture and assay of cell clusters

Diabetes has a massive disease burden worldwide. Despite advances in care, patient morbidity and mortality remain high and there is a need to develop new therapies that improve clinical outcomes. In healthy individuals, beta cells found within…

Investigators

  • Kevin Parker
  • Aaron Glieberman
  • John Ferrier
  • John Zimmerman

Pattern Detection at Low Signal-To-Noise Ratio

Robust detection of patterns at low signal-to-noise ratios (SNR) is a fundamental challenge of analyzing imaging data, particularly in biological imaging. Harvard researchers have developed innovative computational algorithms for detecting and…

Investigators

  • Nancy Kleckner
  • Frederick Chang

A Method for All Solid State Electrode with Superior Energy Density for Lithium Ion Batteries

Solid state batteries are highly sought after in the battery field. Solid state electrolytes (SSE), a central component of these batteries, offer improved safety as they replace the highly flammable organic solvents typical of conventional liquid…

Investigators

  • Xin Li
  • Luhan Ye
  • William Fitzhugh
  • Fan Wu

Exo-site Enzyme Inhibitor Discovery Platform for Oncology Therapeutics

A startup emerging from David Liu's lab intends to commercialize a small-molecule enzyme inhibitor discovery platform to generate more potent drugs with higher specificity. (Image credit: Rose Lincoln/Harvard Staff Photographer.)Off-target drug…

Investigators

  • David Liu

Method for large-scale production of differentiated neurons

INTRODUCTIONHuman pluripotent stem cells (hPSC’s) can be used to generate a wide variety of somatic cell types. In addition, they can be grown in large numbers and thus can be a tractable source for cell types that are otherwise difficult to…

Investigators

  • Lee Rubin

Evolution of Sequence-Defined Highly Functionalized Nucleic Acid Polymers

DESCRIPTION Template-directed synthesis of modified DNA sequences can provide a rich source of material for generating new therapies featuring modified nucleic acid polymers. The Liu lab has previously developed pioneering methods to generate…

Investigators

  • David Liu

Novel platform for rapid, immunization-free nanobody discovery

This is a novel platform technology that can be used to expedite the development of nanobodies for therapeutic and diagnostic applications by avoiding the need for animal immunization.Nanobodies are single-domain antibodies derived from camelids…

Investigators

  • Andrew Kruse

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