AP2 knock-out mutant mice were developed by Dr. Gokhan Hotamisligil at Harvard Medical School (Science. 1996 Nov 22;274(5291):1377-9). AP2, also known as Fatty Acid-Binding Protein 4 (FABP4), encodes the adipocyte FABP. It plays important roles in different aspects of metabolic syndrome. The aP2- deficient mice have a protection against the development of insulin resistance, and early and advanced atherosclerosis (Nat Rev Endocrinol. 2015 Oct;11(10):592-605). The knockout mice are viable and fertile.
The mice can be used in the following areas:
- Insulin resistance
- Type 2 diabetes
The mouse strain is available for licensing from Harvard University.