DBD Search
Vivian Berlin
Executive Director, HMS
Displaying: 1 - 10 of 75 Results
Invention
Utilizing the herpes simplex virus-based vaccine vectors to develop a COVID-19 vaccine
Researchers in the lab of David Knipe have constructed the HSV-1 based vaccine vector HSV-1 d106S. The vector can express viral, bacterial, or cancer gene products and has been used to induce protective immunity in humanized mice against HIV and…
Investigators
- David M. Knipe
Invention
Regenerative Cell Therapy for Skeletal Muscle Disorders
A startup emerging from Lee Rubin's lab aims to provide a long-term cell therapy regenerative solution for conditions that result in reduced or improper skeletal muscle regeneration. (Image credit: B.D. Colen/Harvard Staff.)Cell therapies hold…
Investigators
- Lee L. Rubin
Invention
Polymixin synergistic novobiocin analogs for efficacious and safer treatment of Gram negative infections
The lipopolysaccharide (LPS) containing outer membrane of Gram-negative bacteria prevent penetration of antibiotics, making them ineffective against infections. Polymyxins, including colistin, bind LPS and disrupt the outer membrane and hence are…
Investigators
- Daniel E. Kahne
Invention
Stapled peptide that inhibits bacterial transporter
Multidrug-resistant infection has become a worldwide epidemic in recent years especially in hospitals and other community-associated settings, causing great suffering of patients and huge healthcare burden. According to CDC, at least 23,000 people…
Investigators
- Martin Karplus
Invention
Novel antibiotics against Gram-negative and drug-resistant bacterial pathogens
Dr. Kahne has a pipeline of programs aimed at developing first-in-class antibiotics:Program I: Potentiator of polymixin, increasing its therapeutic index for treatment of drug-resistant infectionsIn vitro: Novel agent potentiates activity of…
Investigators
- Daniel E. Kahne
Invention
aP2 knock-out mice
AP2 knock-out mutant mice were developed by Dr. Gokhan Hotamisligil at Harvard Medical School (Science. 1996 Nov 22;274(5291):1377-9). AP2, also known as Fatty Acid-Binding Protein 4 (FABP4), encodes the adipocyte FABP. It plays important roles in…
Investigators
- Gokhan S. Hotamisligil
Invention
KRT14-Cre mouse line
Hemizygous Tg(KRT14-cre)1Amc/J (also known as K14-Cre) transgenic mice were developed in the laboratory of Dr. Andrew P. McMahon at Harvard University. The mouse strain harbors Cre recombinase under the control of human keratin-14 promoter, which…
Investigators
- Andrew P. McMahon
Invention
Ngn3-Cre transgenic mice for studying pancreatic development
Hemizygous transgenic Tg(Neurog3-cre/Esr1*)1Dam/J mice (also known as Ngn3/CreERTM) were developed in the laboratory of Dr. Douglas A. Melton at Harvard University. The mice contain a fusion protein of Cre recombinase and mutant mouse estrogen…
Investigators
- Douglas Melton
Invention
Small molecule inhibitors of Zika, dengue and other flaviviruses
Currently, broadly-protective antivirals targeting flaviviruses such as Zika, Dengue and West Nile viruses, are not available. Researchers in the laboratory of Dr. Priscilla Yang have identified a group of small molecules, including a prototype…
Investigators
- Priscilla Yang
Invention
Enhancers of Gene Therapy
Currently available gene therapy technologies rely on either plasmid DNA or viral vector transduction to enable gene transfer. However, such methods often suffer from poor direct expression and insufficient incorporation of foreign genetic material.…
Investigators
- David M. Knipe
- Megan Horn Orzalli