Vivian Berlin

Executive Director, HMS

Displaying: 11 - 19 of 19 Results

Using (-)-indolactam V to induce differentiation of human and mouse embryonic stem cells into pancreatic lineage

• ILV can be used alone, or in combination with growth factors, to direct differentiation of ESCs into pancreatic specification. ILV is effective on human ESC lines and mouse ESC lines. • ILV is effective on human ESC lines HUES 2, 4 and 8. After 4…

Investigators

  • Douglas Melton
  • Shuibing Chen
  • Malgorzata Borowiak
  • Julia L. Fox
  • Stuart L. Schreiber
  • Lee F. Peng
  • Lee L. Rubin
  • Kelvin Lam
  • Lance Davidow

Novel lipid hormone for identifying and treating metabolic disease

Scientists in the Harvard School of Public Health have identified fatty acid C16:1n7-palmitoleate, a novel signaling lipid produced by adipose tissue, that protects mice from the detrimental effects of long-term consumption of high-fat diets. They…

Investigators

  • Gokhan S. Hotamisligil
  • Dariush Mozaffarian
  • Haiming Cao

Cell-based assay for the discovery of glycogen synthase kinase inhibitors

This cell-based assay is applicable to diverse biological systems for discovery of glycogen synthase kinase inhibitors. The inhibition of GSK-3b has dramatic morphogenic effects during the early development of numerous organisms, including humans,…

Investigators

  • Douglas Melton
  • Peter S. Klein

Potent OGT inhibitors for the treatment of cancer and diabetic complications

First-in-class and potent OGT inhibitors The Walker group has developed novel high throughput assays (HTS) and screened 200,000 compounds at the Institute for Chemistry and Cell Biology (ICCB) at Harvard Medical School, and identified several…

Investigators

  • Suzanne Walker Kahne
  • Michael B Lazarus
  • Benjamin J. Gross

Lead compounds for the treatment of pain

The invention is a novel synthetic pathway to the generation of nonpeptidic ligands for the mu opioid class of G-protein coupled receptors. The system uses stereochemical variation and acyclic geometric stereocontrol to generate diversity among its…

Investigators

  • Gregory L. Verdine
  • Bryce A. Harrison
  • Tiffany Kaye Malinky Gierasch
  • Zhangjie Shi

Induced motor neurons (iMNs)

The team converted mouse and human fibroblasts into iMNs by the forced expression of select transcription factors. Producing motor neurons this way is much less labor intensive than having to go through the process of creating induced pluripotent…

Investigators

  • Kevin Carl Eggan
  • Justin K. Ichida
  • Esther Yesde Son
  • Brian J. Wainger
  • Clifford Woolf

Ultra fast method for chiral catalyst discovery

This invention is a novel method for determining--in less than 24 hours--enantiomeric ratios, percent conversions, and absolute configurations of all members of a chemical library containing at least 10,000 reaction products. Reaction mixtures are…

Investigators

  • Matthew D. Shair
  • Gregory A. Korbel
  • Gojko Lilac

A drug discovery platform using novel labeled uridine analogs contribute to molecular biology research

This invention consists of novel 5-amino deoxyribouridine analogs. The analogs are labeled with a radioactive or fluorescent moiety and incorporated into nucleic acid by PCR for use in genomic research applications. One assay design involves a…

Investigators

  • Gregory L. Verdine
  • Michael J. Storek

Modulating gene activity on chondrocytes

Transgenic mice were generated in which the regulatory sequences for the Col2a1 gene were used to drive expression of Cre recombinase in chondrocytes. The strain initiates Cre-mediated recombination predominantly in immature chondrocytes and the…

Investigators

  • Andrew P. McMahon
  • Fanxin Long

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