Vivian Berlin

Executive Director, HMS

Displaying: 21 - 30 of 75 Results

Invention

Ultra fast method for chiral catalyst discovery

This invention is a novel method for determining--in less than 24 hours--enantiomeric ratios, percent conversions, and absolute configurations of all members of a chemical library containing at least 10,000 reaction products. Reaction mixtures are…

Investigators

  • Matthew D. Shair
  • Gregory A. Korbel
  • Gojko Lilac

Invention

Using (-)-indolactam V to induce differentiation of human and mouse embryonic stem cells into pancreatic lineage

• ILV can be used alone, or in combination with growth factors, to direct differentiation of ESCs into pancreatic specification. ILV is effective on human ESC lines and mouse ESC lines. • ILV is effective on human ESC lines HUES 2, 4 and 8. After 4…

Investigators

  • Douglas Melton
  • Shuibing Chen
  • Malgorzata Borowiak
  • Julia L. Fox
  • Stuart L. Schreiber
  • Lee F. Peng
  • Lee L. Rubin
  • Kelvin Lam
  • Lance Davidow

Research Tool

Noggin Knock Out Mice

Homozygous mice are born but die shortly after birth, exhibiting multiple defects, including an open neural tube, skeletal abnormalities, shortened body axis, and a small vestigial tail. Analysis of early gene expression has shown that the loss of…

Investigators

  • Andrew P. McMahon

Research Tool

Uba6flox/flox Targeted Mutation Mice

These Uba6flox/flox mutant mice possess loxP sites flanking exons 16-17 of the ubiquitin-like modifier activating enzyme 6 (Uba6) gene. Uba6 (E1) is part of the ubiquitin proteasome system (UPS) which regulates protein homeostasis during…

Research Tool

Akr1b7RFP Trangenic Mice

These transgenic mice express Red Fluorescent Protein (TagRFP-T variant) under the direction of the mouse Akr1b7, aldo-keto reductase family 1, member B7, promoter. Transgene expression is detected at high levels in the adrenal glands and…

Investigators

  • Andrew P. McMahon

Research Tool

Six2-TGCtg EFGPCre Transgenic Mice

Six2-TGCtg mice harbor an ~181 kb BAC transgene with a Tet-off-eGFPCre under control of the Six2 promoter/enhancer regions within the BAC transgene. The Tet-off-eGFPCre contains both the tetracycline-controlled transactivator protein (tTA) as well…

Investigators

  • Andrew P. McMahon

Research Tool

Irf8 Knock Out Mice

Mice homozygous for this Irf8 knockout allele (Irf8-/-) may be expected to to exhibit some or all of the phenotype published for other Irf8 null mutations on both a C57BL/6J-congenic and mixed genetic background. For example, other Ifr8 null mice…

Investigators

  • Andrew P. McMahon

Research Tool

Wnt7a Knock Out Mice

Mice that are homozygous for the targeted mutation are viable, but sterile. A truncated mRNA transcript is detected during embryogenesis. Homozygotes exhibit ventralization of dorsal limb mesoderm tissues. The variable phenotype includes thickening…

Investigators

  • Andrew P. McMahon

Research Tool

RosaGli3TFlag c/c Transgenic Mice

These RosaGli3TFlag c/c mice contain a floxed-neomycin resistance (neo) cassette and polyadenylation signal, cDNA encoding a FLAG-tagged GLI-Kruppel family member (Gli3) repressor gene, an internal ribosome entry site (IRES), and a Venus yellow…

Investigators

  • Andrew P. McMahon

Research Tool

FoxD1GC Transgenic Mice

Heterozygous mice are viable and fertile, normal in size and do not display any gross physical or behavioral abnormalities. The DI states that the strain is homozygous lethal. The FoxD1GC allele expresses an eGFPCre fusion protein (EGFP and cre…

Investigators

  • Andrew P. McMahon

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