Hemizygous CDK5R1 transgenic mice (C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J, also known as p25 Tg) were developed in the laboratory of a former HHMI investigator Dr. Li-Huei Tsai at Harvard University. The mice express CDK5R1/GFP fusion protein under the regulation of tetracycline-controlled transactivator protein. Animals derived by crossing p25 Tg mice with Tg(Camk2a-tTA) mice, exhibit the hallmark phenotype of Alzheimer's disease and neurodegeneration (Neuron, 2003).
The detailed description can be found here.
The mice can be used as a research tool and to model the following diseases:
- Alzheimer's disease
- Amyotrophic lateral sclerosis (ALS)
The mouse strain is available for licensing from Harvard University and will be provided by The Jackson Laboratory.