Irit Ben-Chelouche

Director of Business Development, Harvard Medical School

Displaying: 31 - 40 of 80 Results

Invention

Small-molecule-triggered intein splicing as a universal switch for protein activation

Researchers in the laboratory of Professor David Liu have used directed evolution techniques to evolve an intein-based molecular switch that transduces binding of a small molecule into the activation of an arbitrary protein of interest. To create…

Investigators

  • David R. Liu
  • Allen R. Buskirk
  • Sun H. Peck

Invention

Novel methods for generating regulatory T-cells

Regulatory T-cells (Tregs) are key mediators of peripheral tolerance that can actively suppress effector T-cells, inhibit inflammation and mediate self-tolerance. Unlike naturally occurring Tregs (nTregs) which develop in the thymus,…

Investigators

  • Arlene H. Sharpe
  • Loise Francisco
  • Vijay K. Kuchroo

Invention

A system for the continuous directed evolution of biomolecules

Researchers in the laboratory of Professor David Liu have developed a platform that enables the continuous directed evolution of gene-encoded molecules that can be linked to protein production in E. coli. During phage-assisted continuous evolution…

Investigators

  • David R. Liu
  • Kevin M. Esvelt
  • Jacob Carlson
  • Ahmed Hussein Badran

Invention

Interaction-dependent PCR: Multiplexed identification of ligand-target pairs from DNA-encoded ligand/target libraries in a single solution-phase experiment

IDPCR is based on the melting temperature difference between duplex DNA formed intramolecularly versus intermolecularly. Binding of a target to its ligand would increase the effective molarity of single-stranded DNA oligonucleotides linked to the…

Investigators

  • David R. Liu
  • David J. Gorin
  • Adam S. Kamlet
  • Lynn McGregor
  • Christoph E. Dumelin

Invention

Novel target in NK cell mediated antigen specific memory responses

The von Andrian laboratory discovered a novel mechanism for inducing antigen specific immunological memory. Their research examines the role of a molecular target not previously known to be associated with the natural killer (NK) cell mediated…

Investigators

  • Ulrich H. von Andrian
  • Silke Paust

Invention

Small molecule inhibitors of Ebola virus entry

Background: Human cells that are susceptible to infection by pathogenic viruses express surface membrane proteins that mediate attachment and membrane fusion activity of virus glycoproteins. There are strong structural and functional similarities…

Investigators

  • Dennis Kasper
  • Kyungae Lee
  • Tao Ren
  • James Cunningham
  • Kartik Chandran

Invention

Bisphosphonates as novel adjuvants to enhance the adaptive immune response, validated with common types of vaccine antigens and commercial vaccines

Despite decades of adjuvant research, only a handful of adjuvants have been approved in seven major global markets and only two (Alum and GSK’s AS04) are licensed in the US. The availability of additional adjuvants has been minimized due to…

Investigators

  • Ulrich H. von Andrian
  • Matteo Iannacone
  • Elena Tonti
  • Elliott Ashley Moseman

Invention

Small-molecule macrocycles: Potent and selective Src kinase inhibitors

Macrocyclic compounds have unique properties that allow them to cover regions of chemical space not addressed by other small-molecule structural classes. By performing an in vitro selection screen of a broad untargeted DNA-encoded library of 13,824…

Investigators

  • David R. Liu
  • Ralph Elliot Kleiner

Invention

Fzd2 - novel anti-cancer therapeutic target

The role of β-catenin accumulation in the development of tumorigenicity has been well documented to date, with various mutations in β-catenin, APC, and axin genes typically to blame. Although β-catenin accumulation plays a role in hepatocellular…

Investigators

  • Gavin MacBeath
  • Taran S. Gujral

Invention

SPECT diagnostic agents for Parkinson’s Disease and ADHD

The Harvard research team has over two decades of experience in the design and synthesis of molecules that target monoamine uptake potently and selectively. The class of compounds utilized for the design of the subject SPECT agents is the…

Investigators

  • Bertha Madras
  • Paul Blundell
  • Alan J. Fischman
  • Peter Meltzer
  • Alun G. Jones
  • Ashfaq Mahmood

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