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Displaying: 1 - 10 of 18 Results
Novel annulation catalysts via direct C-H bond amination
Introducing functionality into unactivated C-H bonds, a ubiquitous group in organic molecules, remains a significant challenge due to the inertness of the substrate. Traditional synthesis strategies involve functional group exchange, an inefficient…
DBD
- Christopher Petty
Investigators
- Theodore Betley
- Elisabeth Hennessy
- Alexandre Mikhailine
- Claudia Kleinlein
- Yuyang Dong
- Yunjung Baek
Continuous directed evolution of aminoacyl-tRNA synthetases to alter amino acid specificity and enhance activity
DESCRIPTION Functions of various biotherapeutics can often be enhanced by modifying individual amino acid residues. However, the current approaches rely on existing natural amino acid chemistry. Approaches that provide new chemical “handles” will…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
Studying interactions between essential bacterial ABC (ATP-binding cassette) transporter MsbA and bacterial LPS to pave the way for new antibiotic discovery
Gram-negative bacteria cause multiple infectious disease and are increasingly becoming resistant to antibiotics. However, development of drugs targeting these organisms is complicated by the extreme complexity of the structure of gram-negative cell…
DBD
- Grant Zimmermann
Investigators
- Maofu Liao
Intracellular delivery of proteins: Aurin 1.2, an efficient non-endosomal protein delivery platform
To fully realize the therapeutic potential of proteins, exogenous proteins need to access intracellular targets. Since the vast majority of proteins cannot spontaneously cross cell membranes, a range of delivery platforms have been developed. These…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
First in class substrate-selective Insulin Degrading Enzyme (IDE) inhibitors for treating Diabetes
First in class substrate-selective Insulin Degrading Enzyme (IDE) inhibitors for treating Diabetes. Professor David Liu and a multidisciplinary research team have recently discovered and optimized of a series of small molecules (<550 Da, IC50 = 1…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
- Juan Pablo Maianti
Highly specific chemical detection using NMR at low magnetic fields
NMR often does not have sufficient resolution to distinguish between chemicals with related or similar structures in the presence of a large background, which leads to poor chemical specificity. The NMR spectra of complex chemical mixtures may…
Investigators
- Ronald Walsworth
- Matthew Rosen
- Stephen DeVience
Selective deposition of cells in microwells
This invention is a method of selectively functionalizing indentations (such as wells or channels in microfluidic systems) or protrusions on a substrate such that, for example, cells selectively bind to the indentations or the protrusions. The…
DBD
- Sam Liss
Investigators
- George Whitesides
- Emanuele Ostuni
- Christopher Chen
- Donald Ingber
Microfluidic arrays for multiplex detection of analyts
This invention is a microfluidic array apparatus and a method of performing multiple analyses on multiple samples simultaneously, utilizing nanoliter volumes of reagents. It has two embodiments, the first consists of N microfluidic channels, perhaps…
DBD
- Christopher Petty
Investigators
- George Whitesides
- Rustem Ismagilov
- Jessamine Lee
- Paul Kenis
- Xingyu Jiang
- Rosaria Ferrigno
Highly conformal tungsten nitride films for use in microelectronics and semiconductors
The invention describes a method of producing a uniform, smooth and conformal coating of tungsten nitride, synthesized by atomic layer deposition (ALD). The silver-colored coating (or film) is metallic and a good electrical conductor.
DBD
- Christopher Petty
Investigators
- Roy Gordon
- Jill Becker
- Seigi Suh
Control over deposition of nanoscale materials using structured surfaces
The ability to precisely localize and control deposition of materials at the nanoscale is extremely important for a wide variety of emerging technologies. Many unique physical properties emerge only at the nanoscale and it is very useful to be able…
DBD
- Christopher Petty
Investigators
- Joanna Aizenberg
- Benjamin Hatton