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Displaying: 111 - 120 of 270 Results
The next generation of cholesterol screening - A personalized diagnostic index for the improved assessment of cardiovascular risk using a novel method for the measurement of lipoprotein subtypes
OpportunityThis program offers the next generation of cholesterol screening. In 2013, 96 million visits to doctors' offices in the US included a cholesterol test.Problem/Unmet needCurrent practice of measuring total HDL level in serum does not…
DBD
- Grant Zimmermann
Investigators
- Frank Sacks
Immunology and Computational Biology Partnership
Professors Diane Mathis and Christophe Benoist at Harvard Medical School, together with other world-renowned immunologists and computational biologists from multiple research institutions, have created the Immunological Genome Project – Immgen…
DBD
- Irit Ben-Chelouche
Investigators
- Diane Mathis
- Christophe Benoist
DBD
- Grant Zimmermann
Investigators
- Christopher Murray
- Yidong Ding
- Caroline Alter
- Prasanta Mahapatra
Cell-based assay for the discovery of glycogen synthase kinase inhibitors
This cell-based assay is applicable to diverse biological systems for discovery of glycogen synthase kinase inhibitors. The inhibition of GSK-3b has dramatic morphogenic effects during the early development of numerous organisms, including humans,…
DBD
- Vivian Berlin
Investigators
- Douglas Melton
- Peter Klein
Production and uses of polymerase colony ("polony") arrays
The invention provides methods for rapid fabrication and use of replicable, high-density nucleic acid arrays. Array features are produced through amplification on a support matrix of nucleic acid templates of interest. A significant advance over…
DBD
- Maryanne Fenerjian
Investigators
- George Church
- Robi Mitra
Surface-bound double-stranded DNA protein arrays
Developed at Harvard Medical School, this invention provides nucleic acid arrays specifically designed for the assay of DNA-dependent protein:protein binding and/or physical interactions between proteins and nucleic acid molecules. Intermolecular…
DBD
- Maryanne Fenerjian
Investigators
- George Church
- Martha Bulyk
AlignAce motif searching software
Developed by genomics researchers at Harvard Medical School, AlignAce employs an algorithm that scans non-coding nucleic acid sequences at high resolution for motifs that occur with non-random frequency. This algorithm is built into a multi-level…
DBD
- Maryanne Fenerjian
Investigators
- George Church
- Jason Hughes
- Frederick Roth
Migration inhibitory factor (MIF) knockout mouse
To study the biological role of migration inhibitory factor (MIF), a pleiotropic cytokine, we generated a mouse strain lacking MIF by gene targeting in embryonic stem cells. Analysis of the role of MIF during sepsis showed that MIF-/- mice were…
DBD
- Grant Zimmermann
Investigators
- John David
- Marcelo Bozza
- Craig Gerard
Inhibitors of protein-processivity factor
Harvard investigators have discovered that Pol interacts with a processivity factor at a site that is distinct from sites of normal interaction between known Pol family members and other cellular factors. Unlike most protein-protein interactions,…
DBD
- Grant Zimmermann
Investigators
- Donald Coen
- James Hogle
- Harmon Zuccola
- Kristie Bridges
- Carl Elkin
- Scott Lokey
SPECT diagnostic agents for Parkinson’s Disease and ADHD
The Harvard research team has over two decades of experience in the design and synthesis of molecules that target monoamine uptake potently and selectively. The class of compounds utilized for the design of the subject SPECT agents is the…
DBD
- Irit Ben-Chelouche
Investigators
- Bertha Madras
- Paul Blundell
- Alan Fischman
- Peter Meltzer
- Alun Jones
- Ashfaq Mahmood