Surface-bound double-stranded DNA protein arrays
Developed at Harvard Medical School, this invention provides nucleic acid arrays specifically designed for the assay of DNA-dependent protein:protein binding and/or physical interactions between proteins and nucleic acid molecules. Intermolecular analyses enabled by this technology are advantageously performed in massively-parallel fashion under uniform reaction conditions. This technology enables researchers to:
- Screen for polypeptides that bind nucleic acid sequences of interest.
- Highlight potential gene regulatory elements.
- Identify candidate co-regulated genes based upon their affinity for a given trans-regulator.
- Identify nucleotides or amino acids that mediate specific DNA:protein or protein:protein interactions.
Intellectual Property Status: Patent(s) Pending
Proteomics and pharmacogenomics research; drug development; clinical diagnostic, food and environmental testing.