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Displaying: 11 - 20 of 21 Results
Cell-based assay for the discovery of glycogen synthase kinase inhibitors
This cell-based assay is applicable to diverse biological systems for discovery of glycogen synthase kinase inhibitors. The inhibition of GSK-3b has dramatic morphogenic effects during the early development of numerous organisms, including humans,…
DBD
- Vivian Berlin
Investigators
- Douglas Melton
- Peter Klein
Lead compounds for the treatment of pain
The invention is a novel synthetic pathway to the generation of nonpeptidic ligands for the mu opioid class of G-protein coupled receptors. The system uses stereochemical variation and acyclic geometric stereocontrol to generate diversity among its…
DBD
- Vivian Berlin
Investigators
- Gregory Verdine
- Bryce Harrison
- Tiffany Gierasch
- Zhangjie Shi
A transgenic reporter system can be used for recombination-mediated modulation of gene activity in the developing mouse embryo
A transgenic reporter system consisting of a tamoxifen-inducible form of Cre recombinase (Cre-ERTM) that can be used for recombination-mediated modulation of gene activity in the developing mouse embryo. Using the enhancer of the Wnt1 gene to…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
- Paul Danielian
- David Rowitch
Transgenic mice with fluorescently tagged neuronal mitochondria as a new tool to study axonal transport
Homozygous transgenic mouse stain B6.Cg-Tg(Thy1-CFP/COX8A)S2Lich/J (also know as Thy-CFP-MitoS) was developed by Dr. Jeffrey W. Lichtman at Harvard University. The mice express mitochondria-targeting Cyan Fluorescent Protein (CFP) in neuronal cell…
DBD
- Yelena Bisharyan
Investigators
- Jeffrey Lichtman
- Florence Bareyre
- Thomas Misgeld
- Martin Kerschensteiner
Corticospinal tract (CST)-YFP transgenic mice for monitoring axonal responses to spinal cord injury
Hemizygous transgenic mouse strain B6.Cg-Tg(Thy1-EYFP)15Jrs/J (also known as Thy-STOP-YFP) was developed by Dr. Joshua R. Sanes at Harvard University. The mouse strain harbors an Enhanced Yellow Fluorescent Protein (EYFP) controlled by mouse thymus…
DBD
- Yelena Bisharyan
Investigators
- Joshua Sanes
- Joshua Sanes
- Florence Bareyre
Protein-based therapies using quantitatively designed proteins
A bipartite, quantitatively designed protein having two discrete ligands and a linker; one ligand having the ability to strongly bind to a particular cell, the other having the ability to affect a target only when the previous ligand binds. For many…
DBD
- Grant Zimmermann
Investigators
- Pamela Silver
- Pablo Cironi
- David Miguez
In vitro models and method of treatment for amyotrophic lateral sclerosis (ALS)
It has been impossible to isolate viable human motor neurons from patients or from postmortem samples to investigate the mechanisms leading to neural degeneration in ALS. A potential solution is to use embryonic stem cells (ESC) as a renewable…
DBD
- Vivian Berlin
Investigators
- Kevin Eggan
- Francesco Di Giorgio
Gluconeogenesis as a pro-survival treatment for neurons under stress
A series of AAV-based gene therapy approaches to reprogram certain metabolic enzymes in rod and cone cells in the eye to promote survival in degenerative conditions such as retinitis pigmentosa. Additionally, an independent series of such vectors…
DBD
- Grant Zimmermann
Investigators
- Constance Cepko
- Claudio Punzo
Induced motor neurons (iMNs)
The team converted mouse and human fibroblasts into iMNs by the forced expression of select transcription factors. Producing motor neurons this way is much less labor intensive than having to go through the process of creating induced pluripotent…
DBD
- Vivian Berlin
Investigators
- Kevin Eggan
- Justin Ichida
- Esther Son
- Brian Wainger
- Clifford Woolf
Reproducible Individual Brain Organoids
The human brain is a highly complex organ comprised of a variety of cell types and that are largely generated during embryonic development. While this process is invariable in vivo, it is unclear if this can be recapitulated outside of the embryo.…
DBD
- Yelena Bisharyan
Investigators
- Paola Arlotta