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Displaying: 11 - 19 of 19 Results
Immunology and Computational Biology Partnership
Professors Diane Mathis and Christophe Benoist at Harvard Medical School, together with other world-renowned immunologists and computational biologists from multiple research institutions, have created the Immunological Genome Project – Immgen…
DBD
- Irit Ben-Chelouche
Investigators
- Diane Mathis
- Christophe Benoist
DBD
- Grant Zimmermann
Investigators
- Christopher Murray
- Yidong Ding
- Caroline Alter
- Prasanta Mahapatra
Production and uses of polymerase colony ("polony") arrays
The invention provides methods for rapid fabrication and use of replicable, high-density nucleic acid arrays. Array features are produced through amplification on a support matrix of nucleic acid templates of interest. A significant advance over…
DBD
- Maryanne Fenerjian
Investigators
- George Church
- Robi Mitra
Surface-bound double-stranded DNA protein arrays
Developed at Harvard Medical School, this invention provides nucleic acid arrays specifically designed for the assay of DNA-dependent protein:protein binding and/or physical interactions between proteins and nucleic acid molecules. Intermolecular…
DBD
- Maryanne Fenerjian
Investigators
- George Church
- Martha Bulyk
Microfluidic arrays for multiplex detection of analyts
This invention is a microfluidic array apparatus and a method of performing multiple analyses on multiple samples simultaneously, utilizing nanoliter volumes of reagents. It has two embodiments, the first consists of N microfluidic channels, perhaps…
DBD
- Christopher Petty
Investigators
- George Whitesides
- Rustem Ismagilov
- Jessamine Lee
- Paul Kenis
- Xingyu Jiang
- Rosaria Ferrigno
MicroArray spot LINEar regression (MASLINER) software
Signal intensities between samples on a microarrary typically vary by as much as three to four orders of magnitude, frustrating efforts at comparative analysis of samples assayed in parallel. At any given laser power or photomultiplier tube gain…
DBD
- Maryanne Fenerjian
Investigators
- George Church
- John Aach
- Aimee Dudley
- Martin Steffen
Bead-based polymerase colony microarrays and nucleic acid sequencing ("Polony-FISSEQ Beads")
Foundational work of Dr. George Church has enabled the production and use of replicable arrays of polymerase-amplified nucleic acid colonies (so-called "polonies") on semisolid support matrices (see Harvard Case #1438). The present invention extends…
DBD
- Maryanne Fenerjian
Investigators
- George Church
- Jay Shendure
- Gregory Porreca
- Jun Zhu
Enhanced fidelity of sub-nanogram amplification
The importance of nucleic acid amplification from trace amounts of biological sample has increased with the expansion of genomic sequencing in various clinical and research-oriented applications. This invention characterizes techniques to reduce…
DBD
- Maryanne Fenerjian
Investigators
- George Church
- Kun Zhang
Novel lipid hormone for identifying and treating metabolic disease
Scientists in the Harvard School of Public Health have identified fatty acid C16:1n7-palmitoleate, a novel signaling lipid produced by adipose tissue, that protects mice from the detrimental effects of long-term consumption of high-fat diets. They…
DBD
- Vivian Berlin
Investigators
- Gokhan Hotamisligil
- Dariush Mozaffarian
- Haiming Cao