Harvard Office of Technology Development

A drug discovery platform using novel labeled uridine analogs contribute to molecular biology research

This invention consists of novel 5-amino deoxyribouridine analogs. The analogs are labeled with a radioactive or fluorescent moiety and incorporated into nucleic acid by PCR for use in genomic research applications. One assay design involves a…

Investigators

Gregory L. Verdine
Michael J. Storek

Modulating gene activity on chondrocytes

Transgenic mice were generated in which the regulatory sequences for the Col2a1 gene were used to drive expression of Cre recombinase in chondrocytes. The strain initiates Cre-mediated recombination predominantly in immature chondrocytes and the…

Investigators

Andrew P. McMahon
Fanxin Long

A transgenic reporter system can be used for recombination-mediated modulation of gene activity in the developing mouse embryo

A transgenic reporter system consisting of a tamoxifen-inducible form of Cre recombinase (Cre-ERTM) that can be used for recombination-mediated modulation of gene activity in the developing mouse embryo. Using the enhancer of the Wnt1 gene to…

Investigators

Andrew P. McMahon
Paul S. Danielian
David H. Rowitch

Potent OGT inhibitors for the treatment of cancer and diabetic complications

First-in-class and potent OGT inhibitors The Walker group has developed novel high throughput assays (HTS) and screened 200,000 compounds at the Institute for Chemistry and Cell Biology (ICCB) at Harvard Medical School, and identified several…

Investigators

Suzanne Walker Kahne
Michael B Lazarus
Benjamin J. Gross

Animal model of diabetes and obesity

Mice with the JNK 1 and JNK2 genes knocked out were crossed with the obese mouse line (ob/ob) to create a mouse model of diabetes and obesity. These mice exhibit many of the hallmark metabolic pertubations characteristic in diabetes and obesity.

Investigators

Gokhan S. Hotamisligil
Michael Karin

Cell-based assay for the discovery of glycogen synthase kinase inhibitors

This cell-based assay is applicable to diverse biological systems for discovery of glycogen synthase kinase inhibitors. The inhibition of GSK-3b has dramatic morphogenic effects during the early development of numerous organisms, including humans,…

Investigators

Douglas Melton
Peter S. Klein

In vitro models and method of treatment for amyotrophic lateral sclerosis (ALS)

It has been impossible to isolate viable human motor neurons from patients or from postmortem samples to investigate the mechanisms leading to neural degeneration in ALS. A potential solution is to use embryonic stem cells (ESC) as a renewable…

Investigators

Kevin Carl Eggan
Francesco Paolo Di Giorgio

Lead compounds for the treatment of pain

The invention is a novel synthetic pathway to the generation of nonpeptidic ligands for the mu opioid class of G-protein coupled receptors. The system uses stereochemical variation and acyclic geometric stereocontrol to generate diversity among its…

Investigators

Gregory L. Verdine
Bryce A. Harrison
Tiffany Kaye Malinky Gierasch
Zhangjie Shi

Using (-)-indolactam V to induce differentiation of human and mouse embryonic stem cells into pancreatic lineage

• ILV can be used alone, or in combination with growth factors, to direct differentiation of ESCs into pancreatic specification. ILV is effective on human ESC lines and mouse ESC lines. • ILV is effective on human ESC lines HUES 2, 4 and 8. After 4…

Investigators

Douglas Melton
Shuibing Chen
Malgorzata Borowiak
Julia L. Fox
Stuart L. Schreiber
Lee F. Peng
Lee L. Rubin
Kelvin Lam
Lance Davidow

Novel lipid hormone for identifying and treating metabolic disease

Scientists in the Harvard School of Public Health have identified fatty acid C16:1n7-palmitoleate, a novel signaling lipid produced by adipose tissue, that protects mice from the detrimental effects of long-term consumption of high-fat diets. They…

Investigators

Gokhan S. Hotamisligil
Dariush Mozaffarian
Haiming Cao