Displaying: 21 - 22 of 22 Results

In vitro models and method of treatment for amyotrophic lateral sclerosis (ALS)

It has been impossible to isolate viable human motor neurons from patients or from postmortem samples to investigate the mechanisms leading to neural degeneration in ALS. A potential solution is to use embryonic stem cells (ESC) as a renewable…

Investigators

  • Kevin Carl Eggan
  • Francesco Paolo Di Giorgio

A transgenic reporter system can be used for recombination-mediated modulation of gene activity in the developing mouse embryo

A transgenic reporter system consisting of a tamoxifen-inducible form of Cre recombinase (Cre-ERTM) that can be used for recombination-mediated modulation of gene activity in the developing mouse embryo. Using the enhancer of the Wnt1 gene to…

Investigators

  • Andrew P. McMahon
  • Paul S. Danielian
  • David H. Rowitch

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