Harvard Office of Technology Development

Nuclear Quadrupole Resonance Spectroscopy of a Two-Dimensional Material

The Lukin group's technology provides a way to characterize the properties of atomically-thin samples of 2D materials (e.g., hexagonal boron-nitride, graphene, transition metal dichalcogenides), using nuclear quadrupole resonance (NQR). NQR is a…

Investigators

Mikhail Lukin
Igor Lovchinsky
Hongkun Park

Continuous directed evolution of aminoacyl-tRNA synthetases to alter amino acid specificity and enhance activity

DESCRIPTION Functions of various biotherapeutics can often be enhanced by modifying individual amino acid residues. However, the current approaches rely on existing natural amino acid chemistry. Approaches that provide new chemical “handles” will…

DBD

Irit Ben-Chelouche

Investigators

David Liu

Evolution of Sequence-Defined Highly Functionalized Nucleic Acid Polymers

DESCRIPTION Template-directed synthesis of modified DNA sequences can provide a rich source of material for generating new therapies featuring modified nucleic acid polymers. The Liu lab has previously developed pioneering methods to generate…

DBD

Irit Ben-Chelouche

Investigators

David Liu

Band-gap tunable elastic optical multilayer fibers

Soft photonic fibers that reflect light in the visible spectrum via microscopic multilayer arrangements. The technology is inspired by photonic structures encountered in nature that reflect light to produce vivid and brilliant colors. Key aspects of…

DBD

Christopher Petty

Investigators

Joanna Aizenberg

DNA methylation as a predictor of biological age

Reliable indicators of biological age, rather than chronological age, have been investigated for several decades without much success. Recent studies indicate that epigenetic clock is a reliable predictor of biological age, given its strong…

DBD

Grant Zimmermann

Investigators

Liming Liang

Compounds For Organic Light Emitting Diode Materials

Machine learning promises to radically reduce the cycle time for computational chemistry. This invention is a library of molecules novel deep blue molecule for use in OLED displays, which were identified through the use of machine learning. OLEDs…

DBD

Sam Liss

Investigators

Alan Aspuru-Guzik
Rafael Gomez-Bombarelli
Timothy Hirzel
Jorge Aguilera-Iparraguirre

Novel platform for rapid, immunization-free nanobody discovery

This is a novel platform technology that can be used to expedite the development of nanobodies for therapeutic and diagnostic applications by avoiding the need for animal immunization.Nanobodies are single-domain antibodies derived from camelids…

DBD

Grant Zimmermann

Investigators

Andrew Kruse

Transmitter-receiver for terahertz communication based on a harmonically phase-locked quantum cascade laser

Wi-Fi and cellular data traffic are increasing exponentially but, unless the capacity of wireless links can be increased, all that traffic is bound to lead to unacceptable bottlenecks. Upcoming 5G networks are a temporary fix but not a long-term…

Investigators

Federico Capasso
Marco Piccardo
Dmitry Kazakov

Novel antibiotics against Gram-negative and drug-resistant bacterial pathogens

Dr. Kahne has a pipeline of programs aimed at developing first-in-class antibiotics:Program I: Potentiator of polymixin, increasing its therapeutic index for treatment of drug-resistant infectionsIn vitro: Novel agent potentiates activity of…

DBD

Vivian Berlin

Investigators

Daniel Kahne

SIM-PAL: proteome wide identification of small molecule binding sites

Precise target identification for small molecules is an important and essential step in drug development. Despite its importance, there are very few unbiased, proteome-wide approaches aimed at identifying binding partners for small molecules. In…

DBD

Grant Zimmermann

Investigators

Christina Woo