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Displaying: 11 - 20 of 259 Results

Utilizing the herpes simplex virus-based vaccine vectors to develop a COVID-19 vaccine

Researchers in the lab of David Knipe have constructed the HSV-1 based vaccine vector HSV-1 d106S. The vector can express viral, bacterial, or cancer gene products and has been used to induce protective immunity in humanized mice against HIV and…

DBD

  • Vivian Berlin

Investigators

  • David Knipe

Machine learning to accelerate diagnostics and therapeutics for COVID-19

The COVID-19 pandemic demands a rapid response of science, diagnostics, and therapeutics. Debora Marks’ lab at Harvard Medical School aims to accelerate those efforts using predictive models of the SARS-CoV2-19 sequences and 3D structures. The lab’s…

DBD

  • Irit Ben-Chelouche

Investigators

  • Debora Marks

Novel adjuvants to enhance adaptive immune response of vaccines

Researchers in the lab of Ulrich von Andrian have discovered a novel adjuvanting behavior of a clinically approved and well-tolerated class of medicines known as bisphosphonates. The team is hoping to collaborate with manufacturers of COVID-19…

DBD

  • Irit Ben-Chelouche

Investigators

  • Ulrich von Andrian

Self-adjuvanting mRNA platform technology

Researchers in the lab of Prof. George Church at Harvard Medical School have developed a vaccine platform technology that can be applied to fields such as infectious diseases and oncology therapeutics. The team is looking to further demonstrate…

DBD

  • Grant Zimmermann

Investigators

  • George Church

Stick-on Large-Strain Sensors for Soft Robots

Soft robots require sensors that are soft, stretchable, and conformable to preserve their adaptivity and safety. This technology provides “stick-on” large-strain sensors for soft robots and enables novel functionality for wearable robots, serving as…

DBD

  • Sam Liss

Investigators

  • Robert Howe
  • Zhigang Suo
  • Canhui Yang
  • Sibo Cheng
  • Yashraj Narang

Compounds that block human cytomegalovirus by targeting the nuclear egress complex

Researchers in Dr. Donald Coen’s lab have identified molecules that inhibit human cytomegalovirus (HCMV) virion egress from the cell, effectively inhibiting HCMV replication. The team is looking to expand on these findings in collaborations that…

DBD

  • Grant Zimmermann

Investigators

  • Donald Coen

Cancer Treatment through TRPA1 antagonism

Researchers in Joan Brugge’s lab have identified a new cancer therapeutic target in the ion channel transient receptor potential ankyrin 1 (TRPA1). The lab is seeking collaborations with industry partners to expand on these exciting findings. The…

DBD

  • Grant Zimmermann

Investigators

  • Joan Brugge

Membrane protein nanoparticles for antigen presentation

Researchers in the lab of Dr. James Chou have engineered a new way to display membrane proteins to enhance vaccine immunogenicity using functionalized nanoparticles. The lab has successfully displayed several viral peptides using this technique and…

DBD

  • Grant Zimmermann

Investigators

  • James Chou

Graphene device for terahertz wave generation - opportunities for next gen medical imaging

Terahertz (THz) waves are a desirable source for non-invasive imaging for medical and security purposes, as they are non-ionizing and do not damage tissues. However, generation of THz radiation is significantly more challenging than generating…

DBD

  • Alan Gordon

Investigators

  • Mikhail Lukin
  • Bo Dwyer
  • Trond Andersen
  • Javier Sanchez-Yamagishi
  • Hongkun Park
  • Philip Kim
  • Eugene Demler
  • Kartiek Agarwal

Promising new hand disinfection technology to eliminate pathogens

Pathogens found in the air and on surfaces present a massive global health challenge, threating human health and food security. With the increased prevalence of antibiotic-resistant bacteria and the use of harmful chemicals in typical…

DBD

  • Alan Gordon

Investigators

  • Philip Demokritou
  • Georgios Pyrgiotakis
  • Joseph Brain
  • Nachiket Vaze
  • Mary Eleftheriadou

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